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一名接受卡培他滨和奥沙利铂化疗的结肠癌患者偶然发现主动脉血栓形成。

Incidentally Discovered Aortic Thrombosis in a Patient Undergoing Capecitabine and Oxaliplatin Chemotherapy for Colon Cancer.

作者信息

Burton Kyle A, Gualdoni Steven, Acharya Sheetal

机构信息

Medicine, Upper Peninsula Health System, Marquette, USA.

Medicine, Michigan State University College of Human Medicine, East Lansing, USA.

出版信息

Cureus. 2023 May 15;15(5):e39042. doi: 10.7759/cureus.39042. eCollection 2023 May.

DOI:10.7759/cureus.39042
PMID:37323352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10266507/
Abstract

This case report describes a 68-year-old male who presented to the emergency department (ED) with nausea, vomiting, abdominal pain, diarrhea, and fatigue after starting adjuvant combination chemotherapy with capecitabine and oxaliplatin two weeks prior. Further evaluation of this patient in the ED revealed an incidentally discovered aortic thrombosis, of which this patient did not exhibit any specific symptoms. This case, among a few others, has described the development of arterial thrombosis in patients with cancer undergoing combination chemotherapy with capecitabine and oxaliplatin.

摘要

本病例报告描述了一名68岁男性，他在两周前开始接受卡培他滨和奥沙利铂辅助联合化疗后，因恶心、呕吐、腹痛、腹泻和疲劳而就诊于急诊科（ED）。在急诊科对该患者的进一步评估中，偶然发现了主动脉血栓形成，而该患者并未表现出任何特定症状。该病例以及其他一些病例，均描述了接受卡培他滨和奥沙利铂联合化疗的癌症患者发生动脉血栓形成的情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5fe/10266507/2b131db73aff/cureus-0015-00000039042-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5fe/10266507/bc1a7aa080d9/cureus-0015-00000039042-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5fe/10266507/2b131db73aff/cureus-0015-00000039042-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5fe/10266507/bc1a7aa080d9/cureus-0015-00000039042-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5fe/10266507/2b131db73aff/cureus-0015-00000039042-i02.jpg

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本文引用的文献

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Eur J Cancer. 2023 Mar;181:3-17. doi: 10.1016/j.ejca.2022.11.028. Epub 2022 Dec 9.
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Unexplained arterial thrombosis: approach to diagnosis and treatment.不明原因动脉血栓形成：诊断与治疗方法。
Hematology Am Soc Hematol Educ Program. 2021 Dec 10;2021(1):76-84. doi: 10.1182/hematology.2021000235.
3
[A Case of Severe Aortic Thrombosis during the First Chemotherapy Regimen of CapeOX plus Bevacizumab for Metastatic Colon Cancer].
[1例在采用 CapeOX 加贝伐单抗的首个化疗方案治疗转移性结肠癌期间发生严重主动脉血栓形成的病例]
Gan To Kagaku Ryoho. 2020 Jun;47(6):989-992.
4
Cancer-Associated Thrombosis: An Overview of Mechanisms, Risk Factors, and Treatment.癌症相关血栓形成：机制、危险因素及治疗概述
Cancers (Basel). 2018 Oct 11;10(10):380. doi: 10.3390/cancers10100380.
5
Arterial Thrombosis in Patients with Cancer.癌症患者的动脉血栓形成
Curr Treat Options Cardiovasc Med. 2018 Apr 7;20(5):40. doi: 10.1007/s11936-018-0635-x.
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In the nick of time: arterial thrombosis on starting combination chemotherapy in metastatic gastric adenocarcinoma.在关键时刻：转移性胃腺癌开始联合化疗时发生动脉血栓形成。
BMJ Case Rep. 2016 Feb 25;2016:bcr2015214236. doi: 10.1136/bcr-2015-214236.
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Acute coronary artery thrombosis and vasospasm following capecitabine in conjunction with oxaliplatin treatment for cancer.卡培他滨联合奥沙利铂治疗癌症后出现急性冠状动脉血栓形成和血管痉挛。
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Cardiotoxicity in cancer patients treated with 5-fluorouracil or capecitabine: a systematic review of incidence, manifestations and predisposing factors.接受氟尿嘧啶或卡培他滨治疗的癌症患者的心脏毒性：发生率、表现和易患因素的系统评价。
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