Safari Anahid, Fadakar Nima, Borhani-Haghighi Afshin
Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Basic Clin Neurosci. 2022 Nov-Dec;13(6):807-814. doi: 10.32598/bcn.2021.1971.1. Epub 2022 Nov 1.
Vitamin D deficiency has been linked to the evolution of ischemic stroke, but the data regarding the association between stroke severity and vitamin D level is scarce.
Patients with first-ever ischemic stroke in the middle cerebral artery territory, within seven days after the stroke, were recruited. The control group included age- and gender-matched individuals. We compared 25-OH vitamin D (vitamin D), high sensitive C-reactive protein (hsCRP), serum amyloid A (SAA), and osteopontin levels between stroke patients and the control group. The association between stroke severity according to the National Institutes of Health Stroke Scale (NIHSS) and the Alberta stroke program early CT score (ASPECTS) and levels of vitamin D and inflammatory biomarkers were also studied.
There was an association between hypertension (P=0.035), diabetes mellitus (P=0.043), smoking (P=0.016), history of ischemic heart disease (P=0.002), higher SAA (P<0.001), higher hsCRP (P<0.001), and lower vitamin D levels (P=0.002) and stroke evolution in a case-control study. Meanwhile, in stroke patients, its severity was associated with higher SAA (P=0.04) and hsCRP (P=0.001), and lower vitamin D levels (P=0.043) according to clinical scale (higher admission NIHSS). According to the ASPECT score, higher SAA (P=0.017) and hsCRP (P=0.007), but not lower vitamin D levels, were associated with more infarct areas (P=0.149).
Vitamin D may play a role in both the evolution and severity of stroke.
维生素D缺乏与缺血性中风的发展有关，但关于中风严重程度与维生素D水平之间关联的数据却很稀少。
招募首次发生在大脑中动脉区域的缺血性中风患者，且发病后7天内入院。对照组包括年龄和性别匹配的个体。我们比较了中风患者与对照组之间的25-羟基维生素D（维生素D）、高敏C反应蛋白（hsCRP）、血清淀粉样蛋白A（SAA）和骨桥蛋白水平。还研究了根据美国国立卫生研究院卒中量表（NIHSS）和阿尔伯塔卒中项目早期CT评分（ASPECTS）评估的中风严重程度与维生素D及炎症生物标志物水平之间的关联。
在一项病例对照研究中，高血压（P = 0.035）、糖尿病（P = 0.043）、吸烟（P = 0.016）、缺血性心脏病史（P = 0.002）、较高的SAA（P < 0.001）、较高的hsCRP（P < 0.001）以及较低的维生素D水平（P = 0.002）与中风发展有关。同时，在中风患者中，根据临床量表（较高的入院NIHSS），其严重程度与较高的SAA（P = 0.04）、较高的hsCRP（P = 0.001）以及较低的维生素D水平（P = 0.043）相关。根据ASPECT评分，较高的SAA（P = 0.017）和hsCRP（P = 0.007），而非较低的维生素D水平，与更大的梗死面积相关（P = 0.149）。
维生素D可能在中风的发展和严重程度方面均发挥作用。
