Muscogiuri Giovanna, Annweiler Cedric, Duval Guillaume, Karras Spyridon, Tirabassi Giacomo, Salvio Gianmaria, Balercia Giancarlo, Kimball Samantha, Kotsa Kalliopi, Mascitelli Luca, Bhattoa Harjit Pal, Colao Annamaria
IOS and Coleman Medicina Futura Medical Center, Italy.
Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, Angers, France; University Memory Clinic, UPRES EA 4638, University of Angers, UNAM, Angers, France; Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, Ontario, Canada.
Int J Cardiol. 2017 Mar 1;230:577-584. doi: 10.1016/j.ijcard.2016.12.053. Epub 2016 Dec 26.
There continues to be interest in understanding the role of vitamin D in the pathogenesis, epidemiology and prevention of cardiovascular disease (CVD). In fact vitamin D deficiency has been associated to an increased risk of developing CVD given to the relationship between low vitamin D levels and obesity, diabetes mellitus, dyslipidaemia, endothelial dysfunction and hypertension. However, although vitamin D has been identified as a potentially important marker of CVD, the mechanisms through which vitamin D deficiency leads from endothelial dysfunction to myocardial infarction and stroke are not fully understood. Thus, the goal of this review is to provide an updated review of the literature on the basic science of how vitamin D may affect the cardiovascular system and in particular to analyze the role that vitamin D may have in the whole dynamic process from the initiation of endothelial dysfunction to the development of myocardial infarction and stroke.
对于了解维生素D在心血管疾病（CVD）的发病机制、流行病学及预防中的作用，人们一直保持着兴趣。事实上，鉴于低维生素D水平与肥胖、糖尿病、血脂异常、内皮功能障碍及高血压之间的关系，维生素D缺乏已被认为与患CVD风险增加有关。然而，尽管维生素D已被确定为CVD的一个潜在重要标志物，但维生素D缺乏从内皮功能障碍发展到心肌梗死和中风的机制尚未完全明确。因此，本综述的目的是提供关于维生素D如何影响心血管系统的基础科学文献的最新综述，特别是分析维生素D在从内皮功能障碍开始到心肌梗死和中风发生的整个动态过程中可能发挥的作用。
