Gorodilova V V
Vopr Onkol. 1979;25(3):37-43.
This work sums up the immunological studies performed clinically and delineates the trends of further investigations in active non-specific, specific and passive immunotherapy associated with other methods of the treatment--irradiation, surgery, chemotherapy. There are offered 4 phases of the clinical study on the immunological effect on normalization of the cellular and humoral immunity responses in oncological patients: phase I--selecting of the dosage, phase II--studying of the effectiveness of immunostimulation, phase III--a detailed comparative study of new chemical drugs, phase IV--estimating the effectiveness of different schemes of immunotherapy including the combination treatment of oncological patients.
这项工作总结了临床进行的免疫学研究,并阐述了与其他治疗方法(放疗、手术、化疗)相关的主动非特异性、特异性和被动免疫疗法的进一步研究趋势。文中提出了关于肿瘤患者细胞和体液免疫反应正常化的免疫学效应的临床研究的4个阶段:第一阶段——剂量选择;第二阶段——免疫刺激有效性研究;第三阶段——新化学药物的详细对比研究;第四阶段——评估不同免疫疗法方案的有效性,包括肿瘤患者的联合治疗。