发育过程中去神经支配对大鼠骨骼肌膜电位及细胞内钾和钠活性的影响。

Effect of denervation during development upon membrane potential and intracellular potassium and sodium activities of skeletal muscle of the rat.

作者信息

Ward K M, Wareham A C

出版信息

Exp Neurol. 1986 Jul;93(1):261-9. doi: 10.1016/0014-4886(86)90163-9.

Abstract

Potassium and sodium ion-selective microelectrodes were used in vitro to investigate the effect of denervation of fast-twitch skeletal muscle (extensor digitorum longus) at 5 days of age upon subsequent development of the resting membrane potential. Normally, during the first 3 weeks of life the balance of intracellular potassium and sodium changed to elevate potassium and to lower sodium. These changes were reflected in the development of a more hyperpolarized resting membrane. Periods of denervation delayed, or prevented, the changes in ion activities and membrane hyperpolarization from occurring. The results are compared with those found after denervation of adult skeletal muscle.

摘要

采用钾离子和钠离子选择性微电极在体外研究5日龄时对快肌骨骼肌（趾长伸肌）去神经支配对静息膜电位后续发育的影响。正常情况下，在出生后的前三周，细胞内钾离子和钠离子的平衡发生变化，钾离子升高而钠离子降低。这些变化反映在静息膜电位向超极化方向发展。去神经支配的时期延迟或阻止了离子活性的变化和膜超极化的发生。将这些结果与成年骨骼肌去神经支配后的结果进行了比较。