Research Institute of Nephrology, Zhengzhou University, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P. R. China.
Traditional Chinese Medicine Integrated Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P. R. China.
Int J Biol Sci. 2023 May 11;19(9):2678-2694. doi: 10.7150/ijbs.81892. eCollection 2023.
Diabetic kidney disease (DKD) is one of the most common and severe microvascular complications of diabetes mellitus (DM), and has become the leading cause of end-stage renal disease (ESRD) worldwide. Although the exact pathogenic mechanism of DKD is still unclear, programmed cell death has been demonstrated to participate in the occurrence and development of diabetic kidney injury, including ferroptosis. Ferroptosis, an iron-dependent form of cell death driven by lipid peroxidation, has been identified to play a vital role in the development and therapeutic responses of a variety of kidney diseases, such as acute kidney injury (AKI), renal cell carcinoma and DKD. In the past two years, ferroptosis has been well investigated in DKD patients and animal models, but the specific mechanisms and therapeutic effects have not been fully revealed. Herein, we reviewed the regulatory mechanisms of ferroptosis, summarized the recent findings associated with the involvement of ferroptosis in DKD, and discussed the potential of ferroptosis as a promising target for DKD treatment, thereby providing a valuable reference for basic study and clinical therapy of DKD.
糖尿病肾病（DKD）是糖尿病（DM）最常见和最严重的微血管并发症之一，已成为全球终末期肾病（ESRD）的主要原因。尽管 DKD 的确切发病机制仍不清楚，但程序性细胞死亡已被证明参与了糖尿病肾损伤的发生和发展，包括铁死亡。铁死亡是一种由脂质过氧化驱动的铁依赖性细胞死亡形式，已被确定在多种肾脏疾病的发展和治疗反应中发挥重要作用，如急性肾损伤（AKI）、肾细胞癌和 DKD。在过去的两年中，铁死亡在 DKD 患者和动物模型中得到了很好的研究，但具体的机制和治疗效果尚未完全揭示。本文综述了铁死亡的调控机制，总结了最近与铁死亡参与 DKD 相关的发现，并讨论了铁死亡作为 DKD 治疗有希望的靶点的潜力，为 DKD 的基础研究和临床治疗提供了有价值的参考。
