Cucchini F, Barilli A, Bolognesi R, Compostella L, De Domenico R, Javernaro A, Papalia D, Zeppellini R, Cardaioli P
G Ital Cardiol. 1986 May;16(5):385-9.
The aim of this study is to test left ventricular diastolic function in coronary artery disease patients with preserved systolic performance. Two groups of patients (25 coronary artery disease patients with angiographic proved coronary artery stenosis, but with normal hemodynamic and angiographic indices of systolic phase, first group; and 14 normal subjects for control, second group) were tested comparing their systolic and diastolic ventricular function indices, obtained by using a Millar microtip catheter and a computerized program. Systolic ventricular function was similar in the two groups (EF: 0.61 +/- 0.05 vs 0.62 +/- 0.03, p: n.s.; Vmax:120 +/- 28 vs 112 +/- 24 sec-1, p: n.s.), while diastolic indices were significantly different (lowest diastolic pressure: 3.7 +/- 2.4 vs -1.72 +/- 1.45 mmHg, p less than 0.01; end-diastolic pressure: 11.2 +/- 4.2 vs 6.5 +/- 2.8 mmHg, p less than 0.05; T constant: 45 +/- 8 vs 35 +/- 6 mmHg, p less than 0.001; end-diastolic compliance: 2.79 +/- 0.3 X 10(-2) vs 5.68 +/- 0.4 X 10(-2) mmHg-1, p less than 0.001; Kp: 0.041 +/- 0.006 vs 0.003 +/- 0.004 p less than 0.001). In conclusion, impairment of left ventricular diastolic phase may be one of the earliest manifestations of functional alterations of ischemic ventricle.
本研究旨在检测收缩功能正常的冠心病患者的左心室舒张功能。两组患者接受了检测（第一组为25例经血管造影证实有冠状动脉狭窄但收缩期血流动力学和血管造影指标正常的冠心病患者；第二组为14名正常受试者作为对照），比较通过使用米勒微尖端导管和计算机程序获得的心室收缩和舒张功能指标。两组的心室收缩功能相似（射血分数：0.61±0.05对0.62±0.03，p：无统计学意义；最大速度：120±28对112±24秒-1，p：无统计学意义），而舒张指标有显著差异（最低舒张压：3.7±2.4对-1.72±1.45 mmHg，p<0.01；舒张末期压力：11.2±4.2对6.5±2.8 mmHg，p<0.05；T常数：45±8对35±6 mmHg，p<0.001；舒张末期顺应性：2.79±0.3×10(-2)对5.68±0.4×10(-2) mmHg-1，p<0.001；Kp：0.041±0.006对0.003±0.004，p<0.001）。总之，左心室舒张期功能受损可能是缺血性心室功能改变的最早表现之一。
