Technological Institute of Materials & Energy Science (TIMES), Xi'an Key Laboratory of Advanced Photo-Electronics Materials and Energy Conversion Device, School of Electronic Information, Xijing University, Xi'an 710123, PR China.
College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi'an 710021, PR China.
Int J Biol Macromol. 2023 Jul 31;244:125353. doi: 10.1016/j.ijbiomac.2023.125353. Epub 2023 Jun 15.
With the trend of sustainable development and the complex medical environment, there is a strong demand for multimodal antibacterial cellulose wound dressing (MACD) with photothermal therapy (PTT). Herein, a novel MACD fabrication strategy with PTT was proposed and implemented through graft polymerization of an imidazolium ionic liquid monomer containing iron complex anion structure. The fabricated hydrogels exhibited excellent antibacterial properties because of the efficient photothermal conversion ability (68.67 %) of ionic liquids and the intrinsic structural characteristic of quaternary ammonium salts. The antibacterial ratio of cellulosic hydrogel dressings to S. aureus and E. coli could reach 99.57 % and 99.16 %, respectively. Additionally, the fabricated hydrogels demonstrated extremely low hemolysis rates (<5 %) and excellent cell viability (~>85 %). Furthermore, in vivo antibacterial experimental results proved that the fabricated antibacterial dressings could significantly accelerate wound healing. Therefore, the proposed strategy would provide a new method of designing and preparing high-performance cellulose wound dressings.
随着可持续发展的趋势和复杂的医疗环境，人们对具有光热治疗（PTT）的多模式抗菌纤维素伤口敷料（MACD）有强烈的需求。本文通过含有铁配合阴离子结构的离子液体单体的接枝聚合，提出并实施了一种具有 PTT 的新型 MACD 制造策略。由于离子液体的高效光热转换能力（68.67%）和季铵盐的固有结构特性，所制备的水凝胶表现出优异的抗菌性能。纤维素水凝胶敷料对金黄色葡萄球菌和大肠杆菌的抑菌率分别可达 99.57%和 99.16%。此外，所制备的水凝胶还表现出极低的溶血率（<5%）和优异的细胞活力（>85%）。此外，体内抗菌实验结果证明，所制备的抗菌敷料可显著促进伤口愈合。因此，该策略为设计和制备高性能纤维素伤口敷料提供了一种新方法。
