State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China.
State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China.
Ultrasonics. 2023 Sep;134:107064. doi: 10.1016/j.ultras.2023.107064. Epub 2023 Jun 5.
High-intensity focused ultrasound (HIFU) has now been widely used to ablate various benign and malignant tumors. But it is still critical to increase the ablation efficiency in many clinical applications. Dual-frequency HIFU has been proven to be more efficient in ablation, but the principle on selecting the pulse parameters in this method remains to be explored. In this study, the in vitro lesion areas under different pulse repetition frequencies (PRFs), duty ratios, and frequency differences were compared, cavitation activity was also monitored during HIFU exposure. The results showed that different pulse parameters caused different types of lesions. In HIFU therapy, those pulse parameters that maximize the thermal effect, reduce heat dissipation and generate sufficient cavitation activities should be considered. But the method of evaluating or predicting the damage by using the cavitation dose is only applicable to mechanical damage.
高强度聚焦超声（HIFU）现已广泛用于消融各种良性和恶性肿瘤。但在许多临床应用中，仍需要提高消融效率。双频 HIFU 已被证明在消融方面更有效，但在这种方法中选择脉冲参数的原则仍有待探索。在这项研究中，比较了不同脉冲重复频率（PRF）、占空比和频率差下的体外病变面积，还在 HIFU 暴露期间监测了空化活动。结果表明，不同的脉冲参数会导致不同类型的病变。在 HIFU 治疗中，应考虑那些能最大程度地提高热效应、减少热量散失并产生足够空化活动的脉冲参数。但是，使用空化剂量评估或预测损伤的方法仅适用于机械损伤。
