Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Maturitas. 2023 Sep;175:107782. doi: 10.1016/j.maturitas.2023.05.006. Epub 2023 Jun 7.
Menopausal transition, resulting from a decline in estrogen concentrations, may compromise musculoskeletal health. However, it is unclear if early menopause (defined as age at menopause <45 years) and premature ovarian insufficiency (defined as age at menopause <40 years) are associated with increased risk of sarcopenia. The aim of this systematic review and meta-analysis was to synthesize studies evaluating the association between age at menopause and risk of sarcopenia.
A comprehensive search was conducted in PubMed, CENTRAL and Scopus, up to 31 December 2022. Data were expressed as standardized mean difference with 95 % confidence intervals. The I index was employed to evaluate heterogeneity.
Six studies were included in the qualitative and quantitative analysis, with a total of 18,291 post-menopausal women. Compared with women of normal age at menopause (>45 years), women with early menopause demonstrated lower muscle mass, assessed by appendicular skeletal muscle mass/body mass index [standardized mean difference (SMD) -0.14, 95 % confidence interval (CI) -0.20 to -0.07, p < 0.001; I 0%]. However, no differences in muscle strength, assessed by handgrip strength (SMD -0.15, 95 % CI -0.31 to 0.01, p = 0.071; I 72%), and muscle performance, assessed by gait speed (SMD -0.11, 95 % CI -0.29 to 0.05, p = 0.18; I 79%), were found. Women with premature ovarian insufficiency had lower handgrip strength (SMD -0.3, 95 % CI -0.58 to -0.01, p = 0.04; I 74.6 %) and gait speed (SMD -0.13, 95 % CI -0.23 to -0.04, p = 0.004; I 0%) compared with women of normal age at menopause.
Early menopause is associated with reduced muscle mass and premature ovarian insufficiency with reduced muscle strength and performance compared with normal age at menopause.
由于雌激素浓度下降导致的更年期过渡可能会损害骨骼肌肉健康。然而，目前尚不清楚早期绝经（定义为绝经年龄<45 岁）和卵巢早衰（定义为绝经年龄<40 岁）是否与肌肉减少症风险增加有关。本系统评价和荟萃分析的目的是综合评估绝经年龄与肌肉减少症风险之间的关系。
对 PubMed、CENTRAL 和 Scopus 进行全面检索，截至 2022 年 12 月 31 日。数据表示为标准化均数差及 95%置信区间。采用 I 指数评估异质性。
纳入了 6 项定性和定量分析研究，共有 18291 名绝经后女性。与绝经年龄正常的女性（>45 岁）相比，早期绝经女性的四肢骨骼肌质量/体重指数较低[标准化均数差（SMD）-0.14，95%置信区间（CI）-0.20 至-0.07，p<0.001；I 0%]。然而，握力（SMD -0.15，95%CI -0.31 至 0.01，p=0.071；I 72%）和步态速度（SMD -0.11，95%CI -0.29 至 0.05，p=0.18；I 79%）的肌肉力量方面无差异。卵巢早衰的女性握力（SMD -0.3，95%CI -0.58 至-0.01，p=0.04；I 74.6%）和步态速度（SMD -0.13，95%CI -0.23 至-0.04，p=0.004；I 0%）较低，与绝经年龄正常的女性相比。
与绝经年龄正常的女性相比，早期绝经与肌肉质量减少有关，而卵巢早衰与肌肉力量和功能降低有关。
