Institute of Virology, Hannover Medical School, Germany; Cluster of Excellence 2155 RESIST, Germany; German Center for Infection Research, Hannover-Braunschweig Site, Germany.
Institute of Virology, Hannover Medical School, Germany.
Curr Opin Virol. 2023 Aug;61:101336. doi: 10.1016/j.coviro.2023.101336. Epub 2023 Jun 16.
Kaposi sarcoma-associated herpesvirus (KSHV), or human herpesvirus-8, is an oncogenic herpesvirus. Its latency-associated nuclear antigen (LANA) is essential for the persistence of KSHV in latently infected cells. LANA mediates replication of the latent viral genome during the S phase of a dividing cell and partitions episomes to daughter cells by attaching them to mitotic chromosomes. It also mediates the establishment of latency in newly infected cells through epigenetic mechanisms and suppresses the activation of the productive replication cycle. Furthermore, LANA promotes the proliferation of infected cell by acting as a transcriptional regulator and by modulating the cellular proteome through the recruitment of several cellular ubiquitin ligases. Finally, LANA interferes with the innate and adaptive immune system to facilitate the immune escape of infected cells.
卡波西肉瘤相关疱疹病毒（KSHV），又称人类疱疹病毒 8 型，是一种致癌性疱疹病毒。其潜伏相关核抗原（LANA）对于 KSHV 在潜伏感染细胞中的持续存在至关重要。LANA 在分裂细胞的 S 期介导潜伏病毒基因组的复制，并通过将其附着在有丝分裂染色体上来将染色体外体分配给子细胞。它还通过表观遗传机制介导新感染细胞中的潜伏期建立，并抑制有丝分裂的建立。此外，LANA 通过作为转录调节剂发挥作用，并通过招募几种细胞泛素连接酶来调节细胞蛋白质组，从而促进受感染细胞的增殖。最后，LANA 干扰固有和适应性免疫系统，以促进感染细胞的免疫逃逸。
