Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Ministry of Education, Hefei 230032, China.
Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Ministry of Education, Hefei 230032, China.
Int Immunopharmacol. 2023 Aug;121:110453. doi: 10.1016/j.intimp.2023.110453. Epub 2023 Jun 16.
Extracellular matrix (ECM) is a three-dimensional network entity composed of extracellular macromolecules. ECM in synovium not only supports the structural integrity of synovium, but also plays a crucial role in regulating homeostasis and damage repair response in synovium. Obvious disorders in the composition, behavior and function of synovial ECM will lead to the occurrence and development of arthritis diseases such as rheumatoid arthritis (RA), osteoarthritis (OA) and psoriatic arthritis (PsA). Based on the importance of synovial ECM, targeted regulation of the composition and structure of ECM is considered to be an effective measure for the treatment of arthritis disease. This paper reviews the current research status of synovial ECM biology, discusses the role and mechanism of synovial ECM in physiological status and arthritis disease, and summarizes the current strategies for targeting synovial ECM to provide information for the pathogenesis, diagnosis and treatment of arthritis disease.
细胞外基质（ECM）是一种由细胞外大分子组成的三维网络实体。滑膜中的 ECM 不仅支持滑膜的结构完整性，而且在调节滑膜的动态平衡和损伤修复反应方面起着至关重要的作用。滑膜 ECM 的组成、行为和功能明显紊乱，将导致类风湿关节炎（RA）、骨关节炎（OA）和银屑病关节炎（PsA）等关节炎疾病的发生和发展。鉴于滑膜 ECM 的重要性，靶向调节 ECM 的组成和结构被认为是治疗关节炎疾病的有效措施。本文综述了滑膜 ECM 生物学的研究现状，讨论了滑膜 ECM 在生理状态和关节炎疾病中的作用和机制，并总结了目前针对滑膜 ECM 的靶向策略，为关节炎疾病的发病机制、诊断和治疗提供信息。
