Facultad de Ciencias, Universidad Autonoma de Baja California, Carretera Transpeninsular Ensenada-Tijuana No. 3917, Colonia Playitas C.P. 22860, Ensenada, Baja California, Mexico.
Facultad de Ciencias, Universidad Autonoma de Baja California, Carretera Transpeninsular Ensenada-Tijuana No. 3917, Colonia Playitas C.P. 22860, Ensenada, Baja California, Mexico.
Infect Genet Evol. 2023 Sep;113:105465. doi: 10.1016/j.meegid.2023.105465. Epub 2023 Jun 16.
Trypanosoma cruzi is the parasite responsible for Chagas disease. The parasite has been classified into six taxonomic assemblages: TcI-TcVI and TcBat (aka Discrete Typing Units or Near-Clades). No studies have focused on describing the genetic diversity of T. cruzi in the northwestern region of Mexico. Within the Baja California peninsula lives Dipetalogaster maxima, the largest vector species for CD. The study aimed to describe the genetic diversity of T. cruzi within D. maxima. A total of three Discrete Typing Units (DTUs) were found (TcI, TcIV, and TcIV-USA). TcI was the predominant DTU found (∼75% of samples), in concordance with studies from the southern USA, one sample was described as TcIV while the other ∼20% pertained to TcIV-USA, which has recently been proposed to have enough genetic divergence from TcIV, to merit its own DTU. Potential phenotype differences between TcIV and TcIV-USA should be assessed in future studies.
克氏锥虫是导致查加斯病的寄生虫。该寄生虫已被分为六个分类组合：TcI-TcVI 和 TcBat（又称离散型单位或近群）。目前还没有研究专注于描述墨西哥西北部地区克氏锥虫的遗传多样性。在 Baja California 半岛生活着 Dipetalogaster maxima，这是 CD 的最大媒介物种。本研究旨在描述 D. maxima 体内克氏锥虫的遗传多样性。共发现了三个离散型单位（DTUs）（TcI、TcIV 和 TcIV-USA）。TcI 是发现的主要 DTU（约占样本的 75%），与美国南部的研究结果一致，一个样本被描述为 TcIV，而其他约 20%属于 TcIV-USA，最近有人提出，它与 TcIV 的遗传差异足以使其成为自己的 DTU。在未来的研究中，应该评估 TcIV 和 TcIV-USA 之间的潜在表型差异。
