放射性免疫治疗时代的粒子放疗。

Particle radiotherapy in the era of radioimmunotherapy.

机构信息

Department of Radiation Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian, People's Republic of China.

Department of Radiation Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian, People's Republic of China; Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors (Fujian Medical University), Fuzhou, Fujian, People's Republic of China; Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies), Fuzhou, Fujian, People's Republic of China.

出版信息

Cancer Lett. 2023 Jul 28;567:216268. doi: 10.1016/j.canlet.2023.216268. Epub 2023 Jun 17.

DOI:10.1016/j.canlet.2023.216268

PMID:37331583

Abstract

Radiotherapy (RT) is one of the key modalities for cancer treatment, and more than 70% of tumor patients will receive RT during the course of their disease. Particle radiotherapy, such as proton radiotherapy, carbon-ion radiotherapy (CIRT) and boron neutron capture therapy (BNCT), is currently available for the treatment of patients Immunotherapy combined with photon RT has been successfully used in the clinic. The effect of immunotherapy combined with particle RT is an area of interest. However, the molecular mechanisms underlying the effects of combined immunotherapy and particle RT remain largely unknown. In this review, we summarize the properties of different types of particle RT and the mechanisms underlying their radiobiological effects. Additionally, we compared the main molecular players in photon RT and particle RT and the mechanisms involved the RT-mediated immune response.

摘要

放射治疗（RT）是癌症治疗的关键手段之一，超过 70%的肿瘤患者在疾病过程中将接受 RT。粒子放射治疗，如质子放射治疗、碳离子放射治疗（CIRT）和硼中子俘获治疗（BNCT），目前可用于治疗患者。免疫疗法联合光子 RT 已在临床上成功应用。免疫疗法联合粒子 RT 的效果是一个研究热点。然而，联合免疫疗法和粒子 RT 的作用的分子机制在很大程度上仍是未知的。在这篇综述中，我们总结了不同类型的粒子 RT 的特性及其放射生物学效应的机制。此外，我们比较了光子 RT 和粒子 RT 中的主要分子参与者以及涉及 RT 介导的免疫反应的机制。