Department of Chemical and Biological Engineering, University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada.
Department of Chemical and Biological Engineering, University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada.
Int J Pharm. 2023 Jul 25;642:123130. doi: 10.1016/j.ijpharm.2023.123130. Epub 2023 Jun 17.
Thermal conductivity and specific heat capacity are two important parameters for the drying process of pharmaceutical materials during methods such as wet granulation that can be observed in the overall tablet manufacturing process. In this study, a transient line heat source method was used for the first time to determine the thermal conductivity and volumetric specific heat capacity of common pharmaceutical components and binary mixtures, with moisture content ranging from 0 % to 30 % w.b and active ingredient loading between 0 % and 50 % by weight. A three-parameter least squares regression model relating the thermal properties to moisture content and porosity was evaluated at a 95 % confidence interval, with R values ranging from 0.832 to 0.997. Relationships were established between thermal conductivity, volumetric specific heat capacity, porosity, and moisture content for pharmaceutical ingredients including acetaminophen, microcrystalline cellulose, and lactose monohydrate.
热导率和比热容是湿法制粒等方法中药物材料干燥过程的两个重要参数，这些方法可以在整个片剂制造过程中观察到。在这项研究中，首次使用瞬态线热源法来确定常见药物成分和二元混合物的热导率和容积比热容，其含水量范围为 0%至 30%w.b，活性成分负载量为 0%至 50%重量。在 95%置信区间内，对与水分含量和孔隙率相关的热性能的三参数最小二乘回归模型进行了评估，R 值范围为 0.832 至 0.997。建立了包括对乙酰氨基酚、微晶纤维素和乳糖一水合物在内的药物成分的热导率、容积比热容、孔隙率和水分含量之间的关系。
