早期从静脉用抗生素切换为口服抗生素治疗耐甲氧西林金黄色葡萄球菌菌血症相关的骨和关节感染。
Early switching from intravenous to oral antibiotic therapy in bone and joint infections associated with methicillin-susceptible Staphylococcus aureus bacteremia.
机构信息
Department of Internal Medicine and Infectious Diseases, Reims Teaching Hospitals, Reims, France.
Department of Bacteriology, Reims Teaching Hospitals, Reims, France.
出版信息
Infect Dis Now. 2023 Sep;53(6):104739. doi: 10.1016/j.idnow.2023.104739. Epub 2023 Jun 16.
OBJECTIVES
We aimed to evaluate the clinical outcomes of patients with bone and joint infection (BJI) associated with methicillin-susceptible Staphylococcus aureus bacteremia (MSSAB) treated with early oral switch to oral antibiotics (before day 14) versus later or no switch.
PATIENTS AND METHODS
We included all cases reported between January 2016 and December 2021 in the University Hospital of Reims.
RESULTS
Among 79 patients with BJI associated with MSSAB, 50.6% had an early switch to oral antibiotics, with median duration of intravenous antibiotics of 9 (IQR 6-11) days. The overall cure rate was 81% with follow-up of 6 months, and was 85.7% after excluding the 9 patients whose death was not related to BJI infection. Failure to control BJI did not differ between the two groups.
CONCLUSION
An early (before day 14) switch to oral antibiotics may be a safe therapeutic option in BJI associated with MSSAB.
目的
我们旨在评估治疗耐甲氧西林金黄色葡萄球菌菌血症（MSSAB）相关骨和关节感染（BJI）患者的临床结局，这些患者在第 14 天之前或之后进行早期口服抗生素转换与不进行转换的情况。
患者和方法
我们纳入了 2016 年 1 月至 2021 年 12 月在兰斯大学医院报告的所有病例。
结果
在 79 例与 MSSAB 相关的 BJI 患者中，50.6%进行了早期口服抗生素转换，静脉内抗生素的中位持续时间为 9（IQR 6-11）天。在 6 个月的随访中，总体治愈率为 81%，在排除 9 例与 BJI 感染无关的死亡患者后，治愈率为 85.7%。两组在 BJI 控制失败方面没有差异。
结论
在 MSSAB 相关 BJI 中，早期（第 14 天之前）进行口服抗生素转换可能是一种安全的治疗选择。
Zotero 插件