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接种 COVID-19 疫苗后的自身免疫性肝炎:35 例报告病例的临床特征。

Autoimmune hepatitis following COVID-19 vaccination: Clinical characteristics of 35 reported cases.

机构信息

Qingdao Municipal Hospital, Qingdao, China.

Qingdao Women and Children's Hospital, Qingdao, China.

出版信息

Drug Discov Ther. 2023 Jul 12;17(3):177-182. doi: 10.5582/ddt.2023.01022. Epub 2023 Jun 16.

Abstract

The coronavirus disease 2019 (COVID-19) vaccines have been shown to be effective in protecting people from severe disease progression, hospitalisation and death. However, a wide range of side effects have been reported worldwide. New onset or flare-up of autoimmune hepatitis (AIH) is an extremely rare adverse event following COVID-19 vaccination, with the majority of cases presenting with mild symptoms. Unfortunately, there have been cases of fatal complications. In this mini-review, we have summarised the clinical characteristics of a total of 35 currently reported cases of AIH after COVID-19 vaccination and suggest that patients with autoimmune diseases may be at higher risk of developing AIH after vaccination.

摘要

新型冠状病毒病 2019(COVID-19)疫苗已被证明能有效预防严重疾病进展、住院和死亡。然而,全球范围内报告了各种各样的副作用。新型冠状病毒肺炎(COVID-19)疫苗接种后新发或加重的自身免疫性肝炎(AIH)是一种极其罕见的不良事件,大多数病例表现为轻度症状。不幸的是,也有致命并发症的病例。在这个小型综述中,我们总结了 COVID-19 疫苗接种后总共 35 例 AIH 的临床特征,并提出自身免疫性疾病患者在接种疫苗后可能有更高的发生 AIH 的风险。

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