Early Origins of Adult Health Research Group, UniSA: Clinical and Health Sciences, University of South Australia, South Australia, Adelaide, Australia.
Preclinical, Imaging and Research Laboratories, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Physiol Rep. 2023 Jun;11(12):e15749. doi: 10.14814/phy2.15749.
Babies born growth restricted are at an increased risk of both poor short-and long-term outcomes. Current interventions to improve fetal growth are ineffective and do not lower the lifetime risk of poor health status. Maternal resveratrol (RSV) treatment increases uterine artery blood flow, fetal oxygenation, and fetal weight. However, studies suggest that diets high in polyphenols such as RSV may impair fetal hemodynamics. We aimed to characterize the effect of RSV on fetal hemodynamics to further assess its safety as an intervention strategy. Pregnant ewes underwent magnetic resonance imaging (MRI) scans to measure blood flow and oxygenation within the fetal circulation using phase contrast-MRI and T oximetry. Blood flow and oxygenation measures were performed in a basal state and then repeated while the fetus was exposed to RSV. Fetal blood pressure and heart rate were not different between states. RSV did not impact fetal oxygen delivery (DO ) or consumption (VO ). Blood flow and oxygen delivery throughout the major vessels of the fetal circulation were not different between basal and RSV states. As such, acute exposure of the fetus to RSV does not directly impact fetal hemodynamics. This strengthens the rationale for the use of RSV as an intervention strategy against fetal growth restriction.
生长受限儿出生后，近期和远期结局不良的风险均增加。目前改善胎儿生长的干预措施无效，不能降低不良健康状况的终生风险。母体白藜芦醇（RSV）治疗可增加子宫动脉血流量、胎儿氧合和胎儿体重。然而，研究表明，RSV 等多酚含量高的饮食可能会损害胎儿血液动力学。我们旨在描述 RSV 对胎儿血液动力学的影响，以进一步评估其作为干预策略的安全性。妊娠母羊接受磁共振成像（MRI）扫描，使用相位对比 MRI 和 T 血氧定量法测量胎儿循环中的血流和氧合。在基础状态下进行血流和氧合测量，然后在胎儿暴露于 RSV 时重复测量。胎儿血压和心率在两种状态下无差异。RSV 不影响胎儿氧输送（DO ）或消耗（VO ）。胎儿循环主要血管的血流和氧输送在基础和 RSV 状态之间没有差异。因此，胎儿急性暴露于 RSV 不会直接影响胎儿血液动力学。这为使用 RSV 作为治疗胎儿生长受限的干预策略提供了合理依据。
