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一项关于双联抗血小板治疗患者使用胃保护措施的回顾性观察研究。

A retrospective observational study of the use of gastroprotection for patients on dual antiplatelet therapy.

作者信息

Wong Ee Woon, Bastian Liam, Wilcock Mike

机构信息

Pharmacist All of Pharmacy Department, Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, TR1 3LJ.

Lead Pharmacist for Digital Services All of Pharmacy Department, Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, TR1 3LJ.

出版信息

Br J Cardiol. 2022 Oct 11;29(4):32. doi: 10.5837/bjc.2022.032. eCollection 2022.

DOI:10.5837/bjc.2022.032
PMID:37332274
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10270298/
Abstract

Dual antiplatelet therapy is recommended for secondary prevention of ischaemic events in coronary artery disease. Some patients, who may be at high bleed risk if other factors are present, should be considered for gastroprotection. In our survey, we assessed whether gastroprotection was prescribed for hospital inpatients, especially high-risk patients, who were receiving dual antiplatelet therapy at discharge, and the type of gastroprotection prescribed. We found that over 13 months, a total of 1,693 patient episodes were prescribed dual antiplatelet therapy at discharge, of which 71% also received gastroprotection. Of the patient episodes who were not prescribed gastroprotection, 46% (223/483) met the criterion of age as a risk factor for gastroprotection. A further 30 episodes met other risk criteria of certain concomitant drugs or prior comorbidity. There is a need among clinicians and pharmacy teams within the hospital for recognition and management of this opportunity to improve the care of these patients.

摘要

双联抗血小板治疗被推荐用于冠心病缺血事件的二级预防。如果存在其他因素,一些可能具有高出血风险的患者应考虑给予胃保护。在我们的调查中,我们评估了对于出院时接受双联抗血小板治疗的住院患者,尤其是高危患者,是否开具了胃保护药物以及所开具的胃保护药物类型。我们发现,在13个月的时间里,共有1693例患者在出院时被开具了双联抗血小板治疗,其中71%的患者还接受了胃保护。在未开具胃保护药物的患者中,46%(223/483)符合作为胃保护风险因素的年龄标准。另有30例符合某些合并用药或既往合并症的其他风险标准。医院内的临床医生和药学团队有必要认识并处理这一改善这些患者护理的机会。

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本文引用的文献

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Association of proton-pump inhibitor use with adverse health outcomes: A systematic umbrella review of meta-analyses of cohort studies and randomised controlled trials.质子泵抑制剂的使用与不良健康结局的关联:队列研究和随机对照试验的荟萃分析的系统综合评价
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2
Clinical Outcomes of Concomitant Use of Proton Pump Inhibitors and Dual Antiplatelet Therapy: A Systematic Review and Meta-Analysis.质子泵抑制剂与双联抗血小板治疗联合使用的临床结局:一项系统评价和荟萃分析。
Front Pharmacol. 2021 Aug 2;12:694698. doi: 10.3389/fphar.2021.694698. eCollection 2021.
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Res Social Adm Pharm. 2021 Nov;17(11):1907-1922. doi: 10.1016/j.sapharm.2021.02.009. Epub 2021 Feb 14.
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Pharmacoepidemiol Drug Saf. 2020 Dec;29(12):1659-1668. doi: 10.1002/pds.5122. Epub 2020 Oct 13.
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Evaluation of a pharmacist-led actionable audit and feedback intervention for improving medication safety in UK primary care: An interrupted time series analysis.评价药剂师主导的可操作审核和反馈干预对改善英国初级保健药物安全的效果:一项中断时间序列分析。
PLoS Med. 2020 Oct 13;17(10):e1003286. doi: 10.1371/journal.pmed.1003286. eCollection 2020 Oct.
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Acute Coronary Syndrome, Antiplatelet Therapy, and Bleeding: A Clinical Perspective.急性冠状动脉综合征、抗血小板治疗与出血:临床视角
J Clin Med. 2020 Jul 1;9(7):2064. doi: 10.3390/jcm9072064.
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Urgent Hospital Admissions Caused by Adverse Drug Reactions and Medication Errors-A Population-Based Study in Spain.药物不良反应和用药错误导致的紧急住院情况——西班牙一项基于人群的研究
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