Kalbfell Rachel M, Rettke Devin J, Mackie Ken, Ejima Keisuke, Harezlak Jaroslaw, Alexander Isabella L, Wager-Miller Jim, Johnson Blair D, Newman Sharlene D, Kawata Keisuke
Department of Kinesiology, Indiana University School of Public Health-Bloomington, Bloomington, IN, USA.
Bioethics Research Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
iScience. 2023 May 25;26(6):106948. doi: 10.1016/j.isci.2023.106948. eCollection 2023 Jun 16.
Cannabis use has become popular among athletes, many of whom are exposed to repetitive subconcussive head impacts. We aimed to test whether chronic cannabis use would be neuroprotective or exacerbating against acute subconcussive head impacts. This trial included 43 adult soccer players (Cannabis group using cannabis at least once a week for the past 6 months, n = 24; non-cannabis control group, n = 19). Twenty soccer headings, induced by our controlled heading model, significantly impaired ocular-motor function, but the degrees of impairments were less in the cannabis group compared to controls. The control group significantly increased its serum S100B level after heading, whereas no change was observed in the cannabis group. There was no group difference in serum neurofilament light levels at any time point. Our data suggest that chronic cannabis use may be associated with an enhancement of oculomotor functional resiliency and suppression of the neuroinflammatory response following 20 soccer headings.
大麻的使用在运动员中变得很普遍，其中许多人会遭受重复性的轻度脑震荡性头部撞击。我们旨在测试长期使用大麻对急性轻度脑震荡性头部撞击是具有神经保护作用还是会加剧损伤。该试验纳入了43名成年足球运动员（大麻组：在过去6个月中每周至少使用一次大麻，n = 24；非大麻对照组，n = 19）。由我们的可控头球模型诱发的20次头球显著损害了眼动功能，但与对照组相比，大麻组的损伤程度较小。对照组在头球后血清S100B水平显著升高，而大麻组未观察到变化。在任何时间点，两组血清神经丝轻链水平均无差异。我们的数据表明，长期使用大麻可能与20次头球后眼动功能恢复力增强和神经炎症反应受到抑制有关。
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