Blyden G T, Abernethy D R, Greenblatt D J
Int J Clin Pharmacol Ther Toxicol. 1986 May;24(5):225-6.
The effect of ketoconazole on the kinetics of antipyrine was investigated. The antipyrine Vd showed an overall difference among the 4 trials, but the magnitude of the differences was small. Antipyrine half-life was slightly but not significantly shortened and the antipyrine clearance was essentially identical in the whole study. The data are commented and interpreted.
研究了酮康唑对安替比林药代动力学的影响。安替比林的分布容积在4项试验中总体存在差异，但差异幅度较小。安替比林半衰期略有缩短但无显著差异，且在整个研究中安替比林清除率基本相同。对数据进行了评论和解释。
