Golzar Maryam, Saghi Effat, Rakhshandeh Hassan, Dehnavi Zahra, Jafarzadeh Esfehani Ali, Nematy Mohsen
Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.
Avicenna J Phytomed. 2023 Mar-Apr;13(2):165-176. doi: 10.22038/AJP.2022.21314.
Obesity is an important public health concern in the world. Considering the limited medications and their side effects and lack of a known effective way to reduce appetite, traditional herbs have been considered a complementary treatment for obesity. Therefore, this study was conducted to evaluate the effect of an Iranian Traditional Medicine (ITM)-based herbal candy on body composition and appetite in obese and overweight adults.
In this preliminary study that conducted in nutrition clinic of Ghaem Hospital of Mashhad, participants were selected from overweight and obese people and randomly assigned to either groups. Participants in the intervention group received herbal candy which contained a combination of , , and peanut oil, while participants in the control group received placebo candy for 8 weeks. The primary (appetite response, and weight changes) and secondary (body mass index (BMI), anthropometric parameters, blood pressure, and laboratory variables) outcomes were collected at baseline and during the intervention.
Fifty participants between the age of 18 and 65 years old were included in this study. Herbal candy resulted in a greater reduction in mean weight and BMI compared to placebo (p<0.001). Mean of hunger, satiety, and eating capacity indicators decreased more significantly at all three intervals (30 min after herbal candy, 1 hour after meal and 2 hours after meal) at lunch and dinner meal in the intervention group compared to the control group (p<0.05).
A combination of produced herbal candy at a dose of 4 g (2 pcs), given half an hour before each meal for 8 weeks, can be effective in reducing weight and appetite in obese and overweight people.
肥胖是全球重要的公共卫生问题。鉴于治疗肥胖的药物有限且存在副作用，同时缺乏已知有效的降低食欲的方法，传统草药被视为肥胖的一种辅助治疗手段。因此，本研究旨在评估一种基于伊朗传统医学（ITM）的草药糖果对肥胖和超重成年人身体成分及食欲的影响。
在马什哈德加姆医院营养门诊进行的这项初步研究中，从超重和肥胖人群中选取参与者并随机分组。干预组参与者食用含有[具体成分未给出]、[具体成分未给出]和花生油组合的草药糖果，而对照组参与者食用安慰剂糖果，为期8周。在基线期和干预期间收集主要结局指标（食欲反应和体重变化）以及次要结局指标（体重指数（BMI）、人体测量参数、血压和实验室指标）。
本研究纳入了50名年龄在18至65岁之间的参与者。与安慰剂相比，草药糖果使平均体重和BMI的降低幅度更大（p<0.001）。与对照组相比，干预组在午餐和晚餐时，所有三个时间段（食用草药糖果后30分钟、餐后1小时和餐后2小时）的饥饿感、饱腹感和进食能力指标的平均值下降更为显著（p<0.05）。
以4克（2块）的剂量生产的草药糖果，在每餐饭前半小时服用，持续8周，可有效减轻肥胖和超重人群的体重并降低食欲。
