产前使用西地那非治疗严重早发性宫内生长受限后的新生儿心血管功能：STRIDER-NZAus随机安慰剂对照试验的一项子研究
Neonatal Cardiovascular Function after Antenatal Sildenafil for Severe, Early-Onset Intrauterine Growth Restriction: A Substudy of the STRIDER-NZAus Randomized Placebo-Controlled Trial.
作者信息
Harris Sarah L, McKinlay Chris, Groom Katie, Beker Friederike, Kochar Anuradha, Gill Andrew
机构信息
University of Otago, Christchurch, New Zealand.
Canterbury District Health Board, Christchurch, New Zealand.
出版信息
J Pediatr X. 2019 Nov 20;1:100009. doi: 10.1016/j.ympdx.2019.100009. eCollection 2019 Spring.
Abstract
We evaluated the effect of antenatal sildenafil on neonatal cardiovascular function in a subgroup of 27 infants of mothers participating in the STRIDER-NZAus randomized controlled trial. In this small study, we found no association between antenatal sildenafil and neonatal cardiac dysfunction including no pulmonary hypertension in exposed or unexposed infants.
摘要
我们在参与STRIDER-NZAus随机对照试验的母亲所生的27名婴儿亚组中，评估了产前使用西地那非对新生儿心血管功能的影响。在这项小型研究中，我们发现产前使用西地那非与新生儿心脏功能障碍之间没有关联，包括暴露组和未暴露组婴儿均未出现肺动脉高压。
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本文引用的文献
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2
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Lancet Child Adolesc Health. 2018 Feb;2(2):93-102. doi: 10.1016/S2352-4642(17)30173-6. Epub 2017 Dec 7.
3
Clinicians should stop prescribing sildenafil for fetal growth restriction (FGR): comment from the STRIDER Consortium.临床医生应停止开具用于治疗胎儿生长受限（FGR）的西地那非：STRIDER联盟的评论
Ultrasound Obstet Gynecol. 2018 Sep;52(3):295-296. doi: 10.1002/uog.19186. Epub 2018 Aug 6.
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