抗精神病药物使用与定量跟骨超声（QUS）的关联。
Antipsychotic medication use in association with quantitative heel ultrasound (QUS).
作者信息
Azimi Manavi Behnaz, Mohebbi Mohammadreza, Stuart Amanda L, Pasco Julie A, Hodge Jason M, Weerasinghe D Kavindi, Samarasinghe Rasika M, Williams Lana J
机构信息
Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Geelong 3220, Australia.
Barwon Health, Geelong 3220, Australia.
出版信息
Bone Rep. 2023 Jun 8;18:101694. doi: 10.1016/j.bonr.2023.101694. eCollection 2023 Jun.
PURPOSE
Antipsychotic medication use has been associated with decreased bone mineral density; however, less is known whether antipsychotics affect other parameters of bone health. Therefore, the aim of this study was to investigate the association between antipsychotic medication use and quantitative heel ultrasound (QUS) in a population based sample of men and women.
METHODS
Thirty-one antipsychotic users and 155 non-users matched for age and sex were drawn from the Geelong Osteoporosis Study. QUS was undertaken and included the parameters: Broadband ultrasound attenuation (BUA), speed of sound (SOS) and stiffness index (SI). Current medication use, lifestyle factors, anthropometry and socio-economic status were collected. Generalized Estimation Equation models were conducted to determine associations between antipsychotic medication use and each of the QUS parameters, adjusting for covariates.
RESULTS
Antipsychotic users were less active, consumed less alcohol, were more likely to smoke and take antidepressants; otherwise, the groups were similar. After adjusting for age, sex and weight, antipsychotic users had a 7.7 % lower mean BUA [108.70 (95 % CI 104.26-113.14) vs. 116.42 (95 % CI 115.48-117.37) dB/MHz, p = 0.005] and 7.4 % lower mean SI [89.92 (95 % CI 86.89-92.95) vs. 97.30 (95 % CI 96.48-98.12) %, p < 0.001] compared to non-users. Differences in mean SOS between antipsychotic users and non-users failed to reach statistical significance (p = 0.07).
CONCLUSION
Antipsychotic use was associated with lower QUS parameters. The risk of bone deterioration should be considered when antipsychotics are prescribed.
目的
使用抗精神病药物与骨矿物质密度降低有关；然而，对于抗精神病药物是否会影响骨骼健康的其他参数，人们了解较少。因此，本研究的目的是在一个基于人群的男性和女性样本中，调查使用抗精神病药物与定量足跟超声（QUS）之间的关联。
方法
从吉朗骨质疏松症研究中选取31名使用抗精神病药物的患者和155名年龄和性别匹配的未使用者。进行了QUS检查，包括以下参数：宽带超声衰减（BUA）、声速（SOS）和硬度指数（SI）。收集了当前用药情况、生活方式因素、人体测量数据和社会经济状况。采用广义估计方程模型来确定使用抗精神病药物与每个QUS参数之间的关联，并对协变量进行调整。
结果
使用抗精神病药物的患者活动较少，饮酒较少，更有可能吸烟并服用抗抑郁药；除此之外，两组相似。在调整年龄、性别和体重后，与未使用者相比，使用抗精神病药物的患者平均BUA低7.7%[108.70（95%CI 104.26 - 113.14）dB/MHz对116.42（95%CI 115.48 - 117.37）dB/MHz，p = 0.005]，平均SI低7.4%[89.92（95%CI 86.89 - 92.95）%对97.30（95%CI 96.48 - 98.12）%，p < 0.001]。使用抗精神病药物的患者与未使用者之间平均SOS的差异未达到统计学显著性（p = 0.07）。
结论
使用抗精神病药物与较低的QUS参数相关。在开具抗精神病药物处方时，应考虑骨骼退化的风险。
Zotero 插件