Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia.
Int J Med Sci. 2013 Oct 25;10(12):1778-83. doi: 10.7150/ijms.6765. eCollection 2013.
Quantitative ultrasound (QUS) has emerged as a convenient and popular screening tool for osteoporosis. This review aimed to provide basic information on the principle of QUS measurement and discuss the properties of bone reflected by QUS indices. QUS employed high frequency sound waves generated by the device to determine bone health status in humans. In vitro studies showed that QUS indices were significantly associated with bone mineral density (BMD), bone microarchitecture and mechanical parameters. In humans, QUS indices were found to be associated with BMD as well. In addition, QUS could discriminate subjects with and without fracture history and predict risk for future fracture. In conclusion, QUS is able to reflect bone quality and should be used in the screening of osteoporosis, especially in developing countries where dual-X-ray absorptiometry devices are less accessible to the general population.
定量超声（QUS）已成为一种方便且流行的骨质疏松症筛查工具。本综述旨在提供 QUS 测量原理的基本信息，并讨论 QUS 指数所反映的骨骼特性。QUS 采用设备产生的高频声波来确定人体骨骼的健康状况。体外研究表明，QUS 指数与骨矿物质密度（BMD）、骨微观结构和力学参数显著相关。在人体中，也发现 QUS 指数与 BMD 相关。此外，QUS 可以区分有和无骨折病史的受试者，并预测未来骨折的风险。总之，QUS 能够反映骨质量，应用于骨质疏松症的筛查，特别是在双能 X 线吸收仪设备对普通人群较难获取的发展中国家。
