Zhu Mengdi, Xu Menghao, Zhang Jinmin, Zheng Cuihong
Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Physiol. 2023 Jun 2;14:1198873. doi: 10.3389/fphys.2023.1198873. eCollection 2023.
The follicle is the functional unit of the ovary, whereby ovarian development is largely dependent on the development of the follicles themselves. The activation, growth, and progression of follicles are modulated by a diverse range of factors, including reproductive endocrine system and multiple signaling pathways. The Hippo pathway exhibits a high degree of evolutionary conservation between both and mammalian systems, and is recognized for its pivotal role in regulating cellular proliferation, control of organ size, and embryonic development. During the process of follicle development, the components of the Hippo pathway show temporal and spatial variations. Recent clinical studies have shown that ovarian fragmentation can activate follicles. The mechanism is that the mechanical signal of cutting triggers actin polymerization. This process leads to the disruption of the Hippo pathway and subsequently induces the upregulation of downstream CCN and apoptosis inhibitors, thereby promoting follicle development. Thus, the Hippo pathway plays a crucial role in both the activation and development of follicles. In this article, we focused on the development and atresia of follicles and the function of Hippo pathway in these processes. Additionally, the physiological effects of Hippo pathway in follicle activation are also explored.
卵泡是卵巢的功能单位，卵巢的发育在很大程度上依赖于卵泡自身的发育。卵泡的激活、生长和进展受到多种因素的调节，包括生殖内分泌系统和多种信号通路。Hippo通路在果蝇和哺乳动物系统之间表现出高度的进化保守性，并因其在调节细胞增殖、控制器官大小和胚胎发育中的关键作用而被认可。在卵泡发育过程中，Hippo通路的组成部分呈现出时空变化。最近的临床研究表明，卵巢碎片化可以激活卵泡。其机制是切割的机械信号触发肌动蛋白聚合。这个过程导致Hippo通路的破坏，随后诱导下游CCN和凋亡抑制剂的上调，从而促进卵泡发育。因此，Hippo通路在卵泡的激活和发育中都起着至关重要的作用。在本文中，我们重点关注卵泡的发育和闭锁以及Hippo通路在这些过程中的作用。此外，还探讨了Hippo通路在卵泡激活中的生理效应。
