Kruger Robin E, Aziz Farina, Ralston Amy
Reproduction. 2025 May 30;169(6). doi: 10.1530/REP-25-0016. Print 2025 Jun 1.
The Hippo signaling pathway, so named for its massive overgrowth mutant phenotypes, has become one of the most exciting signaling pathways to emerge in the field of reproductive biology. While disruption of Hippo is associated with tumorigenesis in many organs and tissues, relatively less is understood about the normal roles of Hippo signaling in the reproductive organs. Here, we highlight the recent literature illuminating the roles of Hippo pathway members in mouse and human reproduction. We place special emphasis on the inputs and outputs of Hippo signaling during preimplantation development, where Hippo signaling has been extensively studied in both mouse and human. We note a common emerging theme is the critical and highly conserved role of Hippo signaling in epithelia of the reproductive organs. We also discuss human reproductive disorders, whose etiology may be related to dysregulation of Hippo signaling, and possible therapies that have been proposed to correct this dysregulation. Finally, we describe the edge of our knowledge, which currently limits our understanding of Hippo signaling in reproductive health and disease.
河马信号通路因其大量过度生长突变体表型而得名，已成为生殖生物学领域中最令人兴奋的信号通路之一。虽然河马信号通路的破坏与许多器官和组织的肿瘤发生有关，但人们对河马信号通路在生殖器官中的正常作用了解相对较少。在此，我们重点介绍了近期阐明河马信号通路成员在小鼠和人类生殖中作用的文献。我们特别强调植入前发育过程中河马信号通路的输入和输出，在小鼠和人类中对这一过程的河马信号通路都进行了广泛研究。我们注意到一个共同的新出现的主题是河马信号通路在生殖器官上皮中的关键且高度保守的作用。我们还讨论了病因可能与河马信号通路失调有关的人类生殖障碍，以及为纠正这种失调而提出的可能疗法。最后，我们描述了我们知识的边界，目前这限制了我们对河马信号通路在生殖健康和疾病中的理解。
