红细胞分布宽度作为小儿骨髓炎潜在的炎症标志物
Red blood cell distribution width as a potential inflammatory marker in pediatric osteomyelitis.
作者信息
Eldem Irem, Almekdash Mhd Hasan, Almadani Obada, Levent Fatma, Al-Rahawan Mohamad M
机构信息
Department of Pediatrics, Washington University in St. Louis, St. Louis, Missouri.
Health Services Research, Baylor College of Medicine, Houston, Texas.
出版信息
Proc (Bayl Univ Med Cent). 2023 May 11;36(4):443-447. doi: 10.1080/08998280.2023.2209921. eCollection 2023.
BACKGROUND
Red cell distribution width (RDW) has been used in the differential diagnosis of anemia and revealed to be a potential marker of inflammation.
METHOD
We conducted a retrospective study of acute-phase reactant changes in correlation with RDW among pediatric patients with osteomyelitis.
RESULTS
We identified 82 patients whose mean RDW increased on average by 1% during antibiotic therapy (mean 13.9% on admission, 95% CI 13.4-14.3, and 14.9% at the end of antibiotic therapy, 95% CI 14.5-15.4). Overall, the RDW was weakly correlated with absolute neutrophil count (r = -0.21, = 0.001), erythrocyte sedimentation rate (r = -0.17, = 0.007), and C-reactive protein (r = -0.21, = 0.001). The generalized estimating equation model showed a weak negative correlation between RDW and C-reactive protein during the therapy duration (B= -0.03, = 0.008).
CONCLUSIONS
The mild increase in RDW, and its weak negative correlation with other acute-phase reactants during the study course, limits its utility as a therapy response marker in pediatric osteomyelitis.
背景
红细胞分布宽度（RDW）已用于贫血的鉴别诊断，并被发现是一种潜在的炎症标志物。
方法
我们对患有骨髓炎的儿科患者进行了一项回顾性研究，以探讨急性期反应物变化与RDW之间的相关性。
结果
我们纳入了82例患者，其平均RDW在抗生素治疗期间平均增加了1%（入院时平均为13.9%，95%置信区间为13.4 - 14.3；抗生素治疗结束时为14.9%，95%置信区间为14.5 - 15.4）。总体而言，RDW与绝对中性粒细胞计数（r = -0.21，P = 0.001）、红细胞沉降率（r = -0.17，P = 0.007）和C反应蛋白（r = -0.21，P = 0.001）呈弱相关。广义估计方程模型显示在治疗期间RDW与C反应蛋白之间存在弱负相关（B = -0.03，P = 0.008）。
结论
在研究过程中，RDW轻度升高及其与其他急性期反应物的弱负相关，限制了其作为儿科骨髓炎治疗反应标志物的效用。
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