Brodovskaya Anastasia, Kapur Jaideep
Department of Neurology, University of Virginia, Charlottesville, VA, USA.
UVA Brain Institute, University of Virginia, Charlottesville, VA, USA.
Epilepsy Curr. 2022 Nov 28;23(3):169-174. doi: 10.1177/15357597221136961. eCollection 2023 May-Jun.
Mapping neuronal circuits that generate focal to bilateral tonic-clonic seizures is essential for understanding general principles of seizure propagation and modifying the risk of death and injury due to bilateral motor seizures. We used novel techniques developed over the past decade to study these circuits. We propose the general hypothesis that at the mesoscale, seizures follow anatomical projections of the seizure focus, preferentially activating more excitable neurons.
绘制产生局灶性至双侧强直阵挛性癫痫发作的神经回路对于理解癫痫发作传播的一般原则以及降低双侧运动性癫痫发作导致的死亡和损伤风险至关重要。我们使用了过去十年中开发的新技术来研究这些回路。我们提出了一个一般假设，即在中尺度上，癫痫发作遵循癫痫病灶的解剖投射，优先激活更易兴奋的神经元。
