Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; and Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Department of Psychiatry, University of California, San Diego Health, San Diego, California, USA.
Br J Psychiatry. 2023 Nov;223(5):504-506. doi: 10.1192/bjp.2023.81.
Repetitive transcranial magnetic stimulation (rTMS) is used for treatment of late-life depression. In the FOUR-D study, sequential bilateral theta-burst stimulation (TBS) had comparable remission rates to standard bilateral rTMS. Data were analysed from the FOUR-D trial to compare remission rates between two types of rTMS based on the number and class of prior medication trials. The remission rate was higher in participants with ≤1 previous trial (43.9%) than in participants with 2 previous trials (26.5%) or ≥3 previous trials (24.6%; χ² = 6.36, d.f. = 2, = 0.04). Utilising rTMS earlier in late-life depression may lead to better outcomes.
重复经颅磁刺激（rTMS）用于治疗老年期抑郁症。在 FOUR-D 研究中，序贯双侧θ爆发刺激（TBS）与标准双侧 rTMS 的缓解率相当。对 FOUR-D 试验的数据进行了分析，以比较基于先前药物试验次数和种类的两种 rTMS 之间的缓解率。先前药物试验次数≤1 的参与者的缓解率（43.9%）高于先前药物试验次数为 2 次（26.5%）或≥3 次（24.6%）的参与者（χ²=6.36，自由度 df=2，=0.04）。在老年期抑郁症中更早地使用 rTMS 可能会带来更好的结果。
