序贯双侧经颅磁刺激与标准双侧重复经颅磁刺激治疗难治性老年抑郁症中，前期药物治疗对缓解的影响。
Effect of prior pharmacotherapy on remission with sequential bilateral theta-burst versus standard bilateral repetitive transcranial magnetic stimulation in treatment-resistant late-life depression.
机构信息
Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; and Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Department of Psychiatry, University of California, San Diego Health, San Diego, California, USA.
出版信息
Br J Psychiatry. 2023 Nov;223(5):504-506. doi: 10.1192/bjp.2023.81.
Abstract
Repetitive transcranial magnetic stimulation (rTMS) is used for treatment of late-life depression. In the FOUR-D study, sequential bilateral theta-burst stimulation (TBS) had comparable remission rates to standard bilateral rTMS. Data were analysed from the FOUR-D trial to compare remission rates between two types of rTMS based on the number and class of prior medication trials. The remission rate was higher in participants with ≤1 previous trial (43.9%) than in participants with 2 previous trials (26.5%) or ≥3 previous trials (24.6%; χ² = 6.36, d.f. = 2, = 0.04). Utilising rTMS earlier in late-life depression may lead to better outcomes.
摘要
重复经颅磁刺激（rTMS）用于治疗老年期抑郁症。在 FOUR-D 研究中，序贯双侧θ爆发刺激（TBS）与标准双侧 rTMS 的缓解率相当。对 FOUR-D 试验的数据进行了分析，以比较基于先前药物试验次数和种类的两种 rTMS 之间的缓解率。先前药物试验次数≤1 的参与者的缓解率（43.9%）高于先前药物试验次数为 2 次（26.5%）或≥3 次（24.6%）的参与者（χ²=6.36，自由度 df=2，=0.04）。在老年期抑郁症中更早地使用 rTMS 可能会带来更好的结果。
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