Clin Nucl Med. 2023 Aug 1;48(8):714-715. doi: 10.1097/RLU.0000000000004747. Epub 2023 Jun 17.
An 18-year-old woman with intermittent fever, pancytopenia, abnormal liver function, and enlarged lymph nodes and hepatosplenomegaly was clinically suspected as hemophagocytic lymphohistiocytosis. 18 F-FDG PET/CT showed increased metabolism in multiple lymph nodes, which were highly suggestive of lymphoma. No increased CXCR4 expression in lymph nodes was demonstrated on 68 Ga-pentixafor PET/CT. Subsequent right neck lymph node biopsy pathology revealed EBV-associated lymphoproliferative disorders. Our case shows that 68 Ga-pentixafor PET/CT may have potential value in differentiating EBV-associated lymphoproliferative disorders from lymphomas.
一位 18 岁女性，间断发热，全血细胞减少，肝功能异常，伴淋巴结和肝脾肿大，临床疑诊噬血细胞性淋巴组织细胞增生症。18F-FDG PET/CT 示多发淋巴结代谢增高，高度提示淋巴瘤。68Ga- pentixafor PET/CT 示淋巴结 CXCR4 无表达增高。随后行右颈部淋巴结活检病理提示 EBV 相关淋巴组织细胞增生性疾病。本病例提示 68Ga-pentixafor PET/CT 可能有助于鉴别 EBV 相关淋巴组织细胞增生性疾病与淋巴瘤。
