A Fast Magnetic Flux Density Measurement Method With Skip-Echo Acquired Turbo Spin Echo (SATE).

The measurements of magnetic flux density ( B) needed in magnetic resonance electrical impedance tomography (MREIT) and magnetic resonance current density imaging (MRCDI) techniques often utilize spin echo (SE)-based sequences for data acquisition. The low imaging speed of SE-based methods significantly hampers the clinical applications of MREIT and MRCDI. Here, we propose a new sequence for substantially accelerating the acquisition of B measurements. A skip-echo acquired turbo spin echo (SATE) imaging sequence based on the conventional turbo spin echo (TSE) technique was proposed by adding a skip-echo module in front of the TSE acquisition module. The skip-echo module consisted of a series of refocusing pulses without acquisition. In SATE, amplitude-modulated crusher gradients were used to remove the stimulated echo pathways, and the radiofrequency (RF) pulse shape was specially selected to preserve more signals. In efficiency evaluation experiments performed on a spherical gel phantom, we demonstrated that SATE had improved measurement efficiency compared to the conventional TSE sequence via skipping one echo before acquiring signals. The accuracy of the B measurements by SATE was validated against those by the multi-echo injection current nonlinear encoding (ME-ICNE) method, while SATE was able to accelerate the data acquisition up to 10-fold. Volumetric coverage of B maps obtained in the phantom, pork, and human calf illustrated that SATE can reliably measure volumetric B distributions within clinically acceptable time. The proposed SATE sequence provides a fast and effective approach for volumetric coverage of B measurements, greatly facilitating the clinical applications of MREIT and MRCDI techniques.