Wenger C B, Stephenson L A, Durkin M A
J Appl Physiol (1985). 1986 Jul;61(1):227-32. doi: 10.1152/jappl.1986.61.1.227.
To determine the role of neurotransmitter in the response of forearm blood flow (ABF) to local (forearm) skin temperature (Tsk) we measured ABF of six subjects at Tsk from 25 to 40 degrees C before (control) and after brachial plexus block (BPB). Control experiments were conducted in an ambient temperature of 27-29 degrees C, adjusted to minimize the subject's overall thermal sensation. Tsk was regulated by blowing a controlled-temperature airstream through a plastic bag enclosing the arm. We first lowered Tsk to 25 degrees C and after 20 min began to measure ABF with Whitney strain gauges. We then raised Tsk by 2.5 degrees C steps to 40 degrees C and measured ABF every 30 s for at least 10 min at each level of Tsk. Mean ABF rose from 1.1 ml X 100 ml-1 X min-1 at Tsk of 25 degrees C to 2.1 ml X 100 ml-1 X min-1 at 32.5 degrees C to 13.7 ml X 100 ml-1 X min-1 at 40 degrees C in control experiments and from 2.8 to 4.4 to 14.8 ml X 100 ml-1 X min-1 after BPB. The effect of Tsk on ABF was highly significant (P less than 0.0001) but the effect of BPB was not (P approximately equal to 0.2). At thermoneutrality, the effect of Tsk on ABF is largely independent of neural activity, since this effect is unaffected by nerve block.
为了确定神经递质在前臂血流量（ABF）对局部（前臂）皮肤温度（Tsk）反应中的作用，我们在六个受试者的Tsk从25℃至40℃时，于臂丛神经阻滞（BPB）前（对照）和后测量了ABF。对照实验在27 - 29℃的环境温度下进行，该温度经过调节以尽量减少受试者的整体热感觉。通过将控温气流吹过包裹手臂的塑料袋来调节Tsk。我们首先将Tsk降至25℃，20分钟后开始用惠特尼应变仪测量ABF。然后将Tsk以2.5℃的步长升至40℃，并在每个Tsk水平上每隔30秒测量一次ABF，至少测量10分钟。在对照实验中，平均ABF从Tsk为25℃时的1.1 ml×100 ml⁻¹×min⁻¹升至32.5℃时的2.1 ml×100 ml⁻¹×min⁻¹，再升至40℃时的13.7 ml×100 ml⁻¹×min⁻¹；在BPB后则从2.8升至4.4再升至14.8 ml×100 ml⁻¹×min⁻¹。Tsk对ABF的影响非常显著（P＜0.0001），但BPB的影响不显著（P≈0.2）。在热中性状态下，Tsk对ABF的影响在很大程度上独立于神经活动，因为这种影响不受神经阻滞的影响。
