Department of Life Sciences, University of Nicosia, Cyprus.
University of Nicosia Medical School, Cyprus.
J Nutr. 2023 Aug;153(8):2531-2539. doi: 10.1016/j.tjnut.2023.06.017. Epub 2023 Jun 17.
Eating behavior is associated with weight gain in infancy and childhood. Few studies found a bidirectional association between weight gain and eating behavior development in childhood, but there is little data on the association in early infancy, a period critical for the programming of obesity risk.
We investigated the bidirectional association between appetite traits and weight gain during the first year of life.
Participants were part of a cohort of 432 infants born in Cyprus. Appetite traits were measured using the Baby Eating Behavior Questionnaire or the Child Eating Behavior Questionnaire at age 2 to 4 wk, 6 mo, and 12 mo. Weight and length were collected at birth, 4 wk, 6 mo, and 12 mo. Multivariable linear regression was used to analyze associations between appetite traits at 2 to 4 wk and 6 mo and weight for age z-score change (WFAZC) between 4 wk and 6 mo and 6 and 12 mo. Associations were also analyzed in the opposite direction, between WFAZC from birth to 4 wk, 4 wk to 6 mo, and 6 mo to 12 mo and appetite traits at 4 wk, 6 mo, and 12 mo.
Satiety responsiveness (SR) at 2 to 4 wk was associated with lower WFAZC from 4 wk to 6 mo (β: -0.17; 95% CI: -0.30, -0.04) and SR at age 6 mo was associated with lower WFAZC from 6 to 12 mo (β: -0.09; 95% CI: -0.17, -0.02). WFAZC from 4 wk to 6 mo was associated with higher enjoyment of food at 12 mo (β: 0.11; 95% CI: 0.01, 0.20), higher food responsiveness at 12 mo (β: 0.17; 95% CI: 0.04, 0.30), and lower SR at both 6 mo (β: -0.11; 95% CI: -0.21, -0.01) and 12 mo (β: -0.14; 95% CI: -0.24, -0.03).
We found a bidirectional association between weight gain and appetite traits in infancy, suggesting that the effect of postnatal weight gain on obesity development is partly mediated by programming of appetite traits.
婴儿期和儿童期的进食行为与体重增加有关。少数研究发现，儿童期体重增加与进食行为发展之间存在双向关联，但关于婴儿早期体重增加与进食行为发展之间关联的数据很少，而婴儿早期是肥胖风险编程的关键时期。
我们研究了婴儿期第一年食欲特征与体重增加之间的双向关联。
参与者是塞浦路斯队列中 432 名婴儿的一部分。在 2 至 4 周、6 个月和 12 个月时使用婴儿进食行为问卷或儿童进食行为问卷测量食欲特征。在出生时、4 周、6 个月和 12 个月时收集体重和身长。多变量线性回归用于分析 2 至 4 周和 6 个月时的食欲特征与 4 周至 6 个月和 6 个月至 12 个月之间的体重年龄 z 评分变化（WFAZC）之间的关联。还分析了相反方向的关联，即从出生到 4 周、4 周到 6 个月和 6 个月到 12 个月的 WFAZC 与 4 周、6 个月和 12 个月时的食欲特征之间的关联。
2 至 4 周时的饱腹感反应（SR）与 4 至 6 个月时的 WFAZC 降低有关（β：-0.17；95%置信区间：-0.30，-0.04），6 个月时的 SR 与 6 至 12 个月时的 WFAZC 降低有关（β：-0.09；95%置信区间：-0.17，-0.02）。4 至 6 个月的 WFAZC 与 12 个月时对食物的享受增加有关（β：0.11；95%置信区间：0.01，0.20），12 个月时对食物的反应增加有关（β：0.17；95%置信区间：0.04，0.30），6 个月时的饱腹感反应降低（β：-0.11；95%置信区间：-0.21，-0.01），12 个月时的饱腹感反应降低（β：-0.14；95%置信区间：-0.24，-0.03）。
我们发现婴儿期体重增加与食欲特征之间存在双向关联，这表明出生后体重增加对肥胖发展的影响部分是通过食欲特征的编程介导的。
