Department of Internal Medicine "C", "D", & "E", Tel Aviv Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, Israel.
Department of Internal Medicine "C", "D", & "E", Tel Aviv Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, Israel; Infectious Diseases Unit, Tel Aviv Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, Israel.
Clin Chim Acta. 2023 Jul 1;547:117451. doi: 10.1016/j.cca.2023.117451. Epub 2023 Jun 17.
Examiningthe usefulness of C-reactive protein velocity (CRPv) as an early biomarker for the presence of bacteraemia in patients presenting to the Department of Emergency Medicine with acute infection/inflammation and suspected bacteraemia.
A retrospective study examining a cohort of patients who presented to the E.R and in whom blood cultures were taken. CRPv was calculated as the difference in mg/hour/litter between two consecutive CRP tests performed within 12 h.
256 patients were included in the cohort. Using CRPv in patients who at first presented with a relatively low (17.9 ≤ mg/L 1stquartile) CRP concentration, we found an AUC of 0.808 ± 0.038 (p < 0.001) for the presence of positive versus negative blood cultures (what is AUC?). This was better than the AUC that was obtained when the WBC for the same purpose.
CRPv may be a useful biomarker in the identification of patients with suspected bacteremiaand a low CRP-a challenging situation for clinicians who may underestimate the severity of illness in this patient group.
探讨 C 反应蛋白速度（CRPv）作为急诊科急性感染/炎症伴疑似菌血症患者菌血症存在的早期生物标志物的效用。
回顾性研究分析了一组在急诊科就诊并采集血培养的患者。CRPv 计算为在 12 小时内进行的两次连续 CRP 检测之间每小时每升的差异。
共纳入 256 例患者。在首次 CRP 浓度相对较低（17.9≤mg/L 第一四分位数）的患者中使用 CRPv，我们发现阳性血培养与阴性血培养之间的 AUC 为 0.808±0.038（p<0.001）（什么是 AUC？）。这优于白细胞计数（WBC）用于相同目的的 AUC。
CRPv 可能是识别疑似菌血症且 CRP 较低患者的有用生物标志物，对于临床医生来说，这是一个具有挑战性的情况，因为他们可能低估了这群患者的疾病严重程度。
