Mancilla-Corona Cristian O, Sanchez-Alavez Manuel, Pineda-García Gisela, Islas-Limon Julieta Y, Zazueta Oscar E, Lopez-Baena Jonathan V, Rodríguez-Vásquez Jesús I, Serafin-Higuera Idanya R
Centro de Diagnóstico COVID-19, Facultad de Medicina y Psicología, Calzada Tecnológico y Universidad S/N Delegación Mesa de Otay, 22390, Tijuana, BC, Mexico.
Molecular Medicine, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Eur Arch Psychiatry Clin Neurosci. 2025 Feb;275(1):75-88. doi: 10.1007/s00406-023-01638-2. Epub 2023 Jun 19.
Fatigue has been characterized as a post COVID-19 condition known to persist months after SARS-CoV-2 infection. COVID-19 has been reported to be associated with impaired cognitive function, including disorders in attention, memory, information processing, and executive functions. The objective of this study was to determine if post-COVID fatigue, manifested as tiredness while performing low-intensity physical activity, has a detrimental effect on neuropsychological performance, to achieve this, we randomly selected 20 participants with post-COVID fatigue and 20 SARS-CoV-2 negative age-matched controls from a database of 360 residents of Tijuana, Baja California in a cross-sectional study design. All 40 participants responded to a health survey, along with a neuropsychological assessment test via telephone call. Statistical analysis was performed using a multiple linear regression model including the following independent variables: study condition (post-COVID fatigue or negative control), sex, age, years of education, hypertension, asthma, administration of supplemental oxygen during COVID-19 recovery, and the hour at which the evaluation started. Significant regression analysis was obtained for all global parameters of the assessment, including BANFE-2 score (p = 0.021, R Adj. = 0.263), NEUROPSI score (p = 0.008, R Adj. = 0.319), and total errors (p = 0.021, R Adj. = 0.263), with significant regression coefficients for study condition on two global parameters, BANFE-2 score (p = 0.028, β = - 0.371) and NEUROPSI score (p = 0.010, β = -0.428). These findings suggest that the presence of post-COVID fatigue is a factor associated with a decrease in neuropsychological performance.
疲劳已被描述为一种新冠后状况，已知在感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）数月后仍会持续。据报道，新冠与认知功能受损有关，包括注意力、记忆力、信息处理和执行功能方面的障碍。本研究的目的是确定新冠后疲劳（表现为进行低强度体育活动时感到疲倦）是否会对神经心理表现产生不利影响。为实现这一目的，我们在一项横断面研究设计中，从下加利福尼亚州蒂华纳市360名居民的数据库中随机选取了20名有新冠后疲劳的参与者和20名年龄匹配的SARS-CoV-2阴性对照者。所有40名参与者都回应了一项健康调查，并通过电话进行了神经心理评估测试。使用多元线性回归模型进行统计分析，该模型包括以下自变量：研究状况（新冠后疲劳或阴性对照）、性别、年龄、受教育年限、高血压、哮喘、新冠恢复期间是否使用补充氧气以及评估开始的时间。评估的所有总体参数均获得了显著的回归分析结果，包括BANFE-2评分（p = 0.021，调整后R = 0.263）、NEUROPSI评分（p = 0.008，调整后R = 0.319）和总错误数（p = 0.021，调整后R = 0.263），研究状况在两个总体参数BANFE-2评分（p = 0.028，β = -0.371）和NEUROPSI评分（p = 0.010，β = -0.428）上具有显著的回归系数。这些发现表明，新冠后疲劳的存在是与神经心理表现下降相关的一个因素。
