Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, People's Republic of China.
Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, Wuhan, 430071, People's Republic of China.
World J Surg Oncol. 2023 Jun 19;21(1):182. doi: 10.1186/s12957-023-03069-8.
Pulmonary B-cell lymphoma in the extranodal marginal zone of mucosa-associated lymphoid tissue (MALT), a rare tumor originating from bronchial mucosa-associated lymphoid tissue, is the major histologic type of primary pulmonary lymphoma. Combined lung squamous cell carcinoma with pulmonary MALT lymphoma is rare. A 63-year-old male patient presented to the hospital because of a dry cough, and chest CT showed soft tissue density nodules in the upper lobe of the right lung, the boundary was visible lobulation and spiculation, and the middle lobe of the right lung showed patchy shadow, moderate enhancement, associated with bronchial traction. After a multidisciplinary diagnosis and treatment (MDT) discussion, surgical resection was done for the patient, and postoperative pathological results showed pulmonary MALT lymphoma combined with lung squamous carcinoma. For complex pulmonary multiple lesions, judgment needs to be made after MDT discussion, and timely intervention is required for lesions suspicious of malignancy. There are no uniform recommendations for the management of mixed tumors of the lung, and an individualized treatment plan needs to be developed based on the patient's actual condition.
黏膜相关淋巴组织(MALT)外分泌型 B 细胞淋巴瘤,一种罕见的起源于支气管黏膜相关淋巴组织的肿瘤,是原发性肺淋巴瘤的主要组织学类型。合并肺鳞状细胞癌的肺黏膜相关淋巴组织淋巴瘤更为少见。一名 63 岁男性患者因干咳就诊,胸部 CT 显示右肺上叶软组织密度结节,边界可见分叶和毛刺,右肺中叶可见斑片状影,中度强化,伴支气管牵拉。经过多学科诊疗(MDT)讨论,对患者进行了手术切除,术后病理结果显示为肺黏膜相关淋巴组织淋巴瘤合并肺鳞状细胞癌。对于复杂的肺部多发病变,需要在 MDT 讨论后进行判断,并对疑似恶性的病变及时进行干预。对于肺部混合性肿瘤的处理尚无统一的建议,需要根据患者的实际情况制定个体化的治疗方案。