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表现为后天性丘疹的斑块样CD34阳性皮肤纤维瘤

A Plaque-Like CD34-Positive Dermal Fibroma Presenting as an Acquired Papule.

作者信息

Kanji Alpa, Carton James, Hewitt Caroline, Phillips Derrick

机构信息

Dermatology, Imperial College Healthcare NHS (National Health Service) Trust, London, GBR.

Histopathology, Imperial College Healthcare NHS (National Health Service) Trust, London, GBR.

出版信息

Cureus. 2023 May 19;15(5):e39231. doi: 10.7759/cureus.39231. eCollection 2023 May.

DOI:10.7759/cureus.39231
PMID:37337490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10277152/
Abstract

CD34-positive dermal fibromas (PDFs) are cutaneous neoplasms that display a characteristic pattern of superficial dermal spindle cell proliferation on histopathology evaluation. They are clinically heterogenous in presentation and thought to follow a benign course. CD34-PDFs have features that overlap with dermatofibrosarcoma protuberans (DFSP), a locally aggressive low-grade superficial sarcoma. Cytogenetic studies are essential to distinguish the two. This report presents the case of a 38-year-old female with a CD34-PDF on the right antecubital fossa.

摘要

CD34阳性皮肤纤维瘤（PDFs）是一种皮肤肿瘤，在组织病理学评估中显示出特征性的浅表真皮梭形细胞增殖模式。它们在临床表现上具有异质性，被认为病程呈良性。CD34阳性皮肤纤维瘤具有与隆突性皮肤纤维肉瘤（DFSP）重叠的特征，隆突性皮肤纤维肉瘤是一种局部侵袭性的低度浅表肉瘤。细胞遗传学研究对于区分这两者至关重要。本报告介绍了一名38岁女性右侧肘前窝出现CD34阳性皮肤纤维瘤的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/10277152/4934360c20df/cureus-0015-00000039231-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/10277152/fd299eca1b4c/cureus-0015-00000039231-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/10277152/fe63b2721f05/cureus-0015-00000039231-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/10277152/dcff6d7a36a0/cureus-0015-00000039231-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/10277152/4934360c20df/cureus-0015-00000039231-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/10277152/fd299eca1b4c/cureus-0015-00000039231-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/10277152/fe63b2721f05/cureus-0015-00000039231-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/10277152/dcff6d7a36a0/cureus-0015-00000039231-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8752/10277152/4934360c20df/cureus-0015-00000039231-i04.jpg

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本文引用的文献

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Hypocellular Plaque-Like CD34-Positive Dermal Fibroma (Medallion-Like Dermal Dendrocyte Hamartoma) Presenting as a Skin-Colored Dermal Nodule.表现为肤色真皮结节的少细胞斑块状CD34阳性真皮纤维瘤（类勋章样真皮树突状细胞错构瘤）
Pediatr Dermatol. 2016 Jan-Feb;33(1):e16-9. doi: 10.1111/pde.12726. Epub 2015 Dec 8.
2
Medallion-like dermal dendrocyte hamartoma: a case misdiagnosed as neurofibroma.奖章样真皮树突状细胞错构瘤：一例被误诊为神经纤维瘤的病例。
Pediatr Dermatol. 2010 Nov-Dec;27(6):638-42. doi: 10.1111/j.1525-1470.2010.01324.x. Epub 2010 Nov 24.
3
Plaque-like CD34-positive dermal fibroma ("medallion-like dermal dendrocyte hamartoma"): clinicopathologic, immunohistochemical, and molecular analysis of 5 cases emphasizing its distinction from superficial, plaque-like dermatofibrosarcoma protuberans.
斑块样 CD34 阳性真皮纤维瘤（“勋章样真皮树突状细胞瘤样错构瘤”）：5 例临床病理、免疫组化和分子分析，强调其与浅表性、斑块样隆突性皮肤纤维肉瘤的区别。
Am J Surg Pathol. 2010 Feb;34(2):190-201. doi: 10.1097/PAS.0b013e3181c7cf11.
4
Medallion-like dermal dendrocyte hamartoma: the main diagnostic pitfall is congenital atrophic dermatofibrosarcoma.奖章样真皮树突状细胞错构瘤：主要诊断陷阱是先天性萎缩性皮肤纤维肉瘤。
Br J Dermatol. 2009 Jan;160(1):190-3. doi: 10.1111/j.1365-2133.2008.08896.x. Epub 2008 Oct 22.
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Medallion-like dermal dendrocyte hamartoma.奖章样真皮树突状细胞错构瘤
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