Research Center of Analytical Instrumentation, School of Mechanical Engineering, Sichuan University, China.
Analyst. 2023 Jul 10;148(14):3174-3178. doi: 10.1039/d3an00607g.
In this study, we propose a novel ion formation simulation method for electrospray ionization (ESI) and atmosphere pressure interface (API). In this method, not the sheer particle trajectory, but the evolution of droplets and the offspring of gaseous ions are introduced instead. For the first time, the dynamic droplet-to-ion transformation process in the API of ESI-MS is visualized. The results suggest that this model provides a better understanding of the ion evolution mechanism and we propose a way for mass spectrometer structure optimization and ion source parameter adjustment in new aspects.
在这项研究中，我们提出了一种新的用于电喷雾电离（ESI）和大气压接口（API）的离子形成模拟方法。在这种方法中，引入的不是纯粹的粒子轨迹，而是液滴的演变和气相离子的后代。首次可视化了 ESI-MS 的 API 中动态的液滴到离子的转化过程。结果表明，该模型提供了对离子演化机制的更好理解，并且我们提出了一种新的质谱仪结构优化和离子源参数调整的方法。
