Hatipoğlu Filiz, Çetin Neslihan
İzmir Atatürk Training and Research Hospital, Clinic of Nuclear Medicine, İzmir, Turkey.
Ümraniye Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkey.
Mol Imaging Radionucl Ther. 2023 Jun 20;32(2):138-145. doi: 10.4274/mirt.galenos.2022.68094.
We aimed to investigate and compare the role of computed tomography (CT)-based attenuation-corrected images (AC) with non-attenuation-corrected images (NAC) obtained by single-photon emission computed tomography/computed tomography (SPECT/CT) myocardial perfusion imaging (MPI).
The data of 124 patients who were applied one-day stress-rest Tc-99m sestamibi SPECT/CT MPI and who had coronary angiography (CAG) results within ±3 months were retrospectively reviewed. AC and NAC images were visually evaluated by two nuclear medicine specialists in a consensus. CAG results were used as the reference standard.
Specificity, sensitivity, and accuracy were calculated as 66%, 61%, 71%, 79% and 69%, 70% for AC and NAC imaging in the whole group, respectively. There was no statistically significant difference between AC and NAC images for specificity, sensitivity, and accuracy in the male and female subgroups. In the diagnosis of right coronary artery (RCA) disease, CT AC significantly increased the specificity from 87% to 96%. However, in the left anterior descending artery (LAD) region, the specificity was significantly reduced from 95% to 77%.
CT-based AC did not significantly contribute to diagnostic performance for increased specificity for the RCA and reduced specificity in the LAD region. Therefore, AC images should always be evaluated side by side with NAC images to benefit from the different advantages of both techniques.
我们旨在研究并比较基于计算机断层扫描（CT）的衰减校正图像（AC）与单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）心肌灌注成像（MPI）获得的非衰减校正图像（NAC）的作用。
回顾性分析124例接受一日静息-负荷锝-99m 甲氧基异丁基异腈SPECT/CT MPI检查且在±3个月内有冠状动脉造影（CAG）结果的患者数据。由两名核医学专家共同对AC和NAC图像进行视觉评估。CAG结果用作参考标准。
在整个组中，AC成像和NAC成像的特异性、敏感性和准确性分别计算为66%、61%、71%、79%和69%、70%。在男性和女性亚组中，AC和NAC图像在特异性、敏感性和准确性方面无统计学显著差异。在诊断右冠状动脉（RCA）疾病时，CT AC显著提高了特异性，从87%提高到96%。然而，在左前降支（LAD）区域，特异性从95%显著降低至77%。
基于CT的AC对RCA特异性增加和LAD区域特异性降低的诊断性能没有显著贡献。因此，应始终将AC图像与NAC图像并排评估，以利用两种技术的不同优势。
