非糖尿病吸烟和非吸烟成年人的血清锌与牙周炎：2011 - 2014年美国国家健康与营养检查调查（NHANES）

Serum zinc and periodontitis in non-diabetic smoking and non-smoking adults: NHANES 2011-2014.

作者信息

Zhou Fangjing, Yao Shixin, Shan Fanxiu, Zhou Yang

机构信息

Department of Endodontics, Changsha Stomatological Hospital, Hunan University of Chinese Medicine, Changsha, China.

Department of Intensive Care Unit, Second Xiangya Hospital, Central South University, Changsha, China.

出版信息

Oral Dis. 2024 May;30(4):2592-2598. doi: 10.1111/odi.14650. Epub 2023 Jun 20.

DOI:10.1111/odi.14650

PMID:37338088

Abstract

OBJECTIVE

This study aimed to evaluate the association of serum zinc with periodontitis in non-diabetics based on smoking status, using a representative sample of adults in the United States.

METHODS

A total of 1051 participants who underwent full-mouth periodontal examination and serum zinc testing were enrolled from NHANES 2011 to 2014. The covariate-adjusted association of serum zinc concentrations with periodontitis was explored using multivariable logistic regression, restricted cubic spines, and sensitivity analysis.

RESULTS

The mean age of the 1051 adults was 54.5 years, 59.37% were male, and 20.65% had periodontitis. Analysis of the results showed that serum zinc was associated with periodontitis. The overall adjusted odds of periodontitis were 9% (odds ratio [OR]: 0.91; 95% confidence interval [CI]: 0.83-1.00) and 14% (OR: 0.86; 95% CI: 0.75-0.98) for nonsmokers and smokers, respectively. Smokers with T3 serum zinc exhibited a 53% reduction in the fully adjusted odds of periodontitis (OR: 0.47; 95% CI: 0.23-0.96), when compared to the reference group (T1 serum zinc), with serum zinc as the categorical variable.

CONCLUSIONS

Serum zinc levels were associated with the risk of periodontitis in non-diabetic smokers but not non-smokers.

摘要

目的

本研究旨在利用美国成年人的代表性样本，基于吸烟状况评估非糖尿病患者血清锌与牙周炎之间的关联。

方法

从2011年至2014年的美国国家健康和营养检查调查（NHANES）中招募了1051名接受全口牙周检查和血清锌检测的参与者。使用多变量逻辑回归、受限立方样条和敏感性分析来探讨血清锌浓度与牙周炎的协变量调整关联。

结果

1051名成年人的平均年龄为54.5岁，59.37%为男性，20.65%患有牙周炎。结果分析表明血清锌与牙周炎有关。非吸烟者和吸烟者患牙周炎的总体调整后比值分别为9%（比值比[OR]：0.91；95%置信区间[CI]：0.83 - 1.00）和14%（OR：0.86；95%CI：0.75 - 0.98）。当以血清锌作为分类变量时，与参考组（T1血清锌）相比，T3血清锌的吸烟者患牙周炎的完全调整后比值降低了53%（OR：0.47；95%CI：0.23 - 0.96）。