Medicinal Chemistry Division, Curia India Pvt. Ltd (Formerly Albany Molecular Research, Hyderabad Research Centre), MN park, Genome Valley, Turkapally 500078, Hyderabad, India.
Org Lett. 2023 Jun 30;25(25):4610-4614. doi: 10.1021/acs.orglett.3c01150. Epub 2023 Jun 20.
A simple, mild, metal-free catalytic protocol is developed to convert amides to amines. This protocol uses a stable tetrabutylammonium difluorotriphenylsilicate in combination with silanes that generates a highly reactive hydrosilicate species, which enables the reduction of a broad range of amides to amines in moderate to good yields. The attractive features of this protocol include operational simplicity, safety, short reaction times, room temperature reaction, broad substrate scope, and amenable to scale up.
发展了一种简单、温和、无金属的催化方案，用于将酰胺转化为胺。该方案使用稳定的四丁基氟化二苯基硅酸钠与硅烷结合，生成高反应性的硅氢酸盐物种，从而能够以中等至良好的收率将广泛的酰胺还原为胺。该方案的吸引人之处包括操作简单、安全、反应时间短、室温反应、底物范围广且适合放大。
