De Bastiani G, Aldegheri R, Renzi Brivio L, Trivella G
J Bone Joint Surg Br. 1986 Aug;68(4):545-9. doi: 10.1302/0301-620X.68B4.3733828.
We have compared, in rabbits, two techniques of limb lengthening by distraction of the epiphyseal plate using a unilateral external fixation frame. In all cases, 14 mm of symmetrical lengthening without deviation was achieved. With rapid distraction at rates of 1 mm per day (distractional epiphyseolysis) separation of the epiphysis from the metaphysis occurred by day 7, and by day 70 almost complete ossification of the cartilage and the elongated segment was evident. In contrast, slow distraction at 0.25 mm every 12 hours (chondrodiatasis) produced hyperplasia of growth cartilage without any evidence of detachment at 28 days, the end of the distraction period. By day 70 the epiphyseal plate had returned to normal thickness with normal cellular morphology, while the lengthened segment was occupied by ossified tissue. The significance of these findings is discussed.
我们在兔子身上比较了两种使用单侧外固定架通过骨骺板牵张进行肢体延长的技术。在所有病例中，均实现了14毫米的对称延长且无偏差。以每天1毫米的快速牵张速率（牵张性骨骺溶解），到第7天时骨骺与干骺端分离，到第70天时软骨和延长节段几乎完全骨化。相比之下，每12小时以0.25毫米的缓慢牵张速率（软骨扩张术），在牵张期结束的第28天时，生长软骨增生且没有任何分离迹象。到第70天时，骨骺板恢复到正常厚度，细胞形态正常，而延长节段被骨化组织占据。讨论了这些发现的意义。
