严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的突变格局在复制开始前就已形成。
The SARS-CoV-2 mutation landscape is shaped before replication starts.
作者信息
Masone Diego, Alvarez Maria Soledad, Polo Luis Mariano
机构信息
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo (UNCuyo), Instituto de Histología y Embriología de Mendoza (IHEM), Mendoza, Argentina.
Universidad Nacional de Cuyo (UNCuyo), Facultad de Ingeniería, Mendoza, Argentina.
出版信息
Genet Mol Biol. 2023 Jun 19;46(2):e20230005. doi: 10.1590/1678-4685-GMB-2023-0005. eCollection 2023.
Mutation landscapes and signatures have been thoroughly studied in SARS-CoV-2. Here, we analyse those patterns and link their changes to the viral replication tissue in the respiratory tract. Surprisingly, a substantial difference in those patterns is observed in samples from vaccinated patients. Hence, we propose a model to explain where those mutations could originate during the replication cycle.
在严重急性呼吸综合征冠状病毒2（SARS-CoV-2）中，突变图谱和特征已得到充分研究。在此，我们分析这些模式，并将其变化与呼吸道中的病毒复制组织联系起来。令人惊讶的是，在接种疫苗患者的样本中观察到这些模式存在显著差异。因此，我们提出了一个模型来解释这些突变在复制周期中可能的起源位置。
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