Department of Obstetrics and Gynaecology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan, USA.
Department of Life Sciences, School of Sciences, Gujarat University, Ahmedabad, India.
J Eur Acad Dermatol Venereol. 2023 Oct;37(10):2109-2123. doi: 10.1111/jdv.19286. Epub 2023 Jul 14.
Hidradenitis suppurativa (HS) is a chronic, systemic, inflammatory skin condition with elusive pathogenesis that affects therapeutic intervention directly.
To characterize epigenetic variations in cytokines genes contributing to HS.
Epigenome-wide DNA methylation profiling with the Illumina Epic array was performed on blood DNA samples from 24 HS patients and 24 age- and sex-matched controls to explore DNA methylation changes in cytokine genes.
We identified 170 cytokine genes including 27 hypermethylated CpG sites and 143 genes with hypomethylated sites respectively. Hypermethylated genes, including LIF, HLA-DRB1, HLA-G, MTOR, FADD, TGFB3, MALAT1 and CCL28; hypomethylated genes, including NCSTN, SMAD3, IGF1R, IL1F9, NOD2, NOD1, YY1, DLL1 and BCL2 may contribute to the pathogenesis of HS. These genes were enriched in the 117 different pathways (FDR p-values ≤ 0.05), including IL-4/IL-13 pathways and Wnt/β-catenin signalling.
The lack of wound healing, microbiome dysbiosis and increased tumour susceptibility are all sustained by these dysfunctional methylomes, hopefully, capable to be targeted in the next future. Since methylome describes and summarizes genetic and environmental contributions, these data may represent a further step towards a feasible precision medicine also for HS patients.
化脓性汗腺炎（HS）是一种慢性、全身性、炎症性皮肤病，发病机制难以捉摸，直接影响治疗干预。
描述与 HS 相关的细胞因子基因的表观遗传变异。
对 24 例 HS 患者和 24 名年龄和性别匹配的对照者的血液 DNA 样本进行 Illumina Epic 芯片全基因组 DNA 甲基化谱分析，以探讨细胞因子基因的 DNA 甲基化变化。
我们鉴定了 170 个细胞因子基因，包括 27 个高甲基化 CpG 位点和 143 个低甲基化基因。高甲基化基因包括 LIF、HLA-DRB1、HLA-G、MTOR、FADD、TGFB3、MALAT1 和 CCL28；低甲基化基因包括 NCSTN、SMAD3、IGF1R、IL1F9、NOD2、NOD1、YY1、DLL1 和 BCL2，可能与 HS 的发病机制有关。这些基因富集在 117 条不同的途径中（FDR p 值≤0.05），包括 IL-4/IL-13 途径和 Wnt/β-catenin 信号通路。
这些功能失调的甲基组学使伤口愈合不良、微生物组失调和肿瘤易感性增加得以维持，希望在未来能够成为治疗靶点。由于甲基组学描述和总结了遗传和环境的影响，这些数据可能代表了朝着可行的精准医学迈出的又一步，也适用于 HS 患者。
