Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Shushan District, Hefei, 230032, Anhui, China.
Department of Infectious Diseases, Anhui Provincial Children's Hospital, Hefei, Anhui, China.
Int Arch Occup Environ Health. 2023 Oct;96(8):1087-1100. doi: 10.1007/s00420-023-01991-8. Epub 2023 Jun 20.
The effects of air pollution on human health have long been a hot topic of research. For respiratory diseases, a large number of studies have proved that air pollution is one of the main causes. The purpose of this study was to investigate the risk of hospitalization of children with respiratory system diseases (CRSD) caused by six pollutants (PM, PM, NO, SO, CO, and O) in Hefei City, and further calculate the disease burden.
In the first stage, the generalized additive models were combined with the distributed lag non-linear models to evaluate the impact of air pollution on the inpatients for CRSD in Hefei. In the second stage, this study used the cost-of-illness approach to calculate the attributable number of hospitalizations and the extra disease burden.
Overall, all the six kinds of pollutants had the strongest effects on CRSD inpatients within lag10 days. SO and CO caused the highest and lowest harm, respectively, and the RR values were SO (lag0-5): 1.1 20 (1.053, 1.191), and CO (lag0-6): 1.002 (1.001, 1.003). During the study period (January 1, 2014 to December 30, 2020), the 7-year cumulative burden of disease was 36.19 million CNY under the WHO air pollution standards.
In general, we found that six air pollutants were risk factors for CRSD in Hefei City, and create a huge burden of disease.
空气污染对人类健康的影响一直是研究的热点。对于呼吸系统疾病，大量研究已经证明，空气污染是主要原因之一。本研究旨在探讨合肥市六种污染物（PM2.5、PM10、NO、SO2、CO 和 O3）对儿童呼吸系统疾病（CRSD）住院的影响，并进一步计算疾病负担。
在第一阶段，广义加性模型与分布式滞后非线性模型相结合，评估了空气污染对合肥市 CRSD 住院患者的影响。在第二阶段，本研究采用疾病成本法计算住院归因人数和额外疾病负担。
总体而言，六种污染物在滞后 10 天内对 CRSD 住院患者的影响最强。SO2和 CO 造成的危害最高和最低，RR 值分别为 SO2（lag0-5）：1.120（1.053，1.191）和 CO（lag0-6）：1.002（1.001，1.003）。在研究期间（2014 年 1 月 1 日至 2020 年 12 月 30 日），根据世界卫生组织的空气污染标准，7 年的疾病累计负担为 3619 万元人民币。
总的来说，我们发现合肥市的六种空气污染物是 CRSD 的危险因素，并造成了巨大的疾病负担。
