Kazan State Medical University, Ministry of the Health of the Russian Federation, Kazan, Republic of Tatarstan, Russia.
Mayo Clinic, Rochester, Minnesota, USA.
Bull Exp Biol Med. 2023 May;175(1):7-11. doi: 10.1007/s10517-023-05799-x. Epub 2023 Jun 20.
The effect of transtraumatic epidural electrostimulation (TEES) above (T5) and below (L2) spinal cord injury in the lower thoracic region (T8-T9) in combination with treadmill exercise in pigs was evaluated using electrophysiological examination methods and behavioral tests. Two weeks after spinal cord injury, motor evoked potentials of m. soleus were recorded during electrostimulation at the level of T5 and L2 segments, which indicated activation of spinal cord structures above and below the focus of injury. After 6 weeks of TEES in combination with physical training, restoration of the characteristics of M-response and H-reflex of the soleus muscle in response to stimulation of the sciatic nerve, improvement of joint mobility, and appearance of voluntary motor activity in the hindlimbs were observed. Neuromodulation with TEES had been proven to be an effective way to stimulate posttraumatic spinal cord regeneration and can be used in the development of a neurorehabilitation protocol for patients with spinal cord injury.
采用电生理学检查方法和行为学测试，评估了创伤后硬膜外电刺激（TEES）在上胸段（T5）和下胸段（L2）脊髓损伤（T8-T9 下胸段）结合跑步机运动对猪的影响。脊髓损伤后 2 周，在 T5 和 L2 节段进行电刺激时记录比目鱼肌的运动诱发电位，这表明损伤焦点上方和下方的脊髓结构被激活。经过 6 周的 TEES 联合物理训练，观察到对坐骨神经刺激时比目鱼肌 M 反应和 H 反射的特征恢复，关节活动度改善，后肢出现自主运动活动。TEES 的神经调节已被证明是刺激创伤后脊髓再生的有效方法，可用于制定脊髓损伤患者的神经康复方案。
