Tan K, Baxter R C
J Clin Endocrinol Metab. 1986 Sep;63(3):651-5. doi: 10.1210/jcem-63-3-651.
Despite reports of reduced serum insulin-like growth factor (IGF) levels in experimentally diabetic animals, human diabetic patients have been reported to have decreased, normal, or even elevated levels. This study was a cross-sectional examination of the effect of age on immunoreactive IGF-I levels in adult patients with insulin-dependent or noninsulin-dependent diabetes mellitus (IDDM and NIDDM) attending a diabetes out-patient clinic. The patients and normal subjects studied were divided into the age ranges 21-30, 31-40, 41-50, 51-60, and over 60 yr. For all ages combined, the mean IGF-I level (+/- SD) was 0.84 +/- 0.26 U/ml (202 +/- 62 ng/ml) in 133 normal subjects, significantly reduced to 0.41 +/- 0.17 U/ml in 121 IDDM patients, and 0.49 +/- 0.19 U/ml in 46 NIDDM patients (both P less than 0.001). In both groups there was a marked decline in IGF-I with increasing age (P less than 0.01). Except for NIDDM patients aged 21-30 yr (only two patients), IGF-I levels in both IDDM and NIDDM patients were significantly lower in every age range than those in age-matched normal subjects, but did not differ between the two diabetic groups. Glycosylated hemoglobin levels correlated inversely with IGF-I levels only in younger patients with IDDM (r = -0.486; P less than 0.05 for patients aged 21-40 yr). We conclude that factors common to IDDM and NIDDM, perhaps related to relative nutritional deficiency at the cellular level, cause a reduction in serum IGF-I levels, and that this reduction occurs independently of age-related changes in IGF-I.
尽管有报道称实验性糖尿病动物的血清胰岛素样生长因子（IGF）水平降低，但据报道人类糖尿病患者的IGF水平有降低、正常甚至升高的情况。本研究是一项横断面检查，旨在研究年龄对一家糖尿病门诊中胰岛素依赖型或非胰岛素依赖型糖尿病（IDDM和NIDDM）成年患者免疫反应性IGF-I水平的影响。研究的患者和正常受试者被分为21 - 30岁、31 - 40岁、41 - 50岁、51 - 60岁以及60岁以上几个年龄组。所有年龄组综合来看，133名正常受试者的平均IGF-I水平（±标准差）为0.84±0.26 U/ml（202±62 ng/ml），121名IDDM患者显著降至0.41±0.17 U/ml，46名NIDDM患者为0.49±0.19 U/ml（两者P均小于0.001）。两组中IGF-I水平均随年龄增长显著下降（P小于0.01）。除了21 - 30岁的NIDDM患者（仅2例），IDDM和NIDDM患者在每个年龄组的IGF-I水平均显著低于年龄匹配的正常受试者，但两个糖尿病组之间无差异。糖化血红蛋白水平仅在年轻的IDDM患者中与IGF-I水平呈负相关（r = -0.486；21 - 40岁患者P小于0.05）。我们得出结论，IDDM和NIDDM共有的因素，可能与细胞水平的相对营养缺乏有关，导致血清IGF-I水平降低，且这种降低与IGF-I的年龄相关变化无关。
