心房颤动对肥厚型心肌病患者生存预后的影响：一项荟萃分析。
Prognostic effect of atrial fibrillation on survival in patients with hypertrophic cardiomyopathy: a meta-analysis.
机构信息
Department of Cardiology, The First Affiliated Hospital of Hebei North University, No. 12 of Changqing Road, Qiaoxi District, Zhangjiakou, 075000, China.
出版信息
J Cardiothorac Surg. 2023 Jun 20;18(1):196. doi: 10.1186/s13019-023-02299-x.
OBJECTIVE
To systematically evaluate the prognostic impact of atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM).
METHODS
The Chinese and English databases (PubMed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure, and Wanfang database were systematically searched to include observational studies on the prognosis of AF in cardiovascular events or death in patients with HCM; these were evaluated using Revman 5.3.
RESULTS
After systematic search and screening, a total of 11 studies with a high study quality were included in this study. Meta-analysis showed that patients with HCM accompanied by AF had a higher risk of all-cause death (odds ratio [OR] = 2.75; 95% confidence interval [CI]: 2.18-3.47; P < 0.001), heart-related death (OR = 2.62; 95%CI: 2.02-3.40; P < 0.001), sudden cardiac death (OR = 7.09; 95%CI: 5.77-8.70; P < 0.001), heart-failure-related death (OR = 2.04; 95%CI: 1.24-3.36; P = 0.005), and stroke death (OR = 17.05; 95%CI: 6.99-41.58; P < 0.001) compared with patients with HCM without AF.
CONCLUSION
Atrial fibrillation is a risk factor for adverse survival outcomes in patients with HCM, and aggressive interventions are needed in this population to avoid the occurrence of adverse outcomes.
目的
系统评估心房颤动（AF）对肥厚型心肌病（HCM）患者的预后影响。
方法
系统检索中文和英文数据库（PubMed、EMBASE、Cochrane Library、中国知网和万方数据库），纳入关于 AF 对 HCM 患者心血管事件或死亡预后影响的观察性研究；使用 Revman 5.3 进行评估。
结果
经过系统检索和筛选，共有 11 项高质量研究纳入本研究。Meta 分析显示，伴有 AF 的 HCM 患者全因死亡（优势比 [OR] = 2.75；95%置信区间 [CI]：2.18-3.47；P < 0.001）、心脏相关死亡（OR = 2.62；95%CI：2.02-3.40；P < 0.001）、心源性猝死（OR = 7.09；95%CI：5.77-8.70；P < 0.001）、心力衰竭相关死亡（OR = 2.04；95%CI：1.24-3.36；P = 0.005）和卒中相关死亡（OR = 17.05；95%CI：6.99-41.58；P < 0.001）的风险高于无 AF 的 HCM 患者。
结论
AF 是 HCM 患者不良生存结局的危险因素，该人群需要积极干预以避免不良结局的发生。
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