Payne-Johnson C E, Kelly D F, Davies P T
J Comp Pathol. 1986 Jul;96(4):463-7. doi: 10.1016/0021-9975(86)90042-3.
A 2-years-old nulliparous cross-bred bitch had persistent vulval discharge following treatments that included a combined ethinyloestradiol/methyltestosterone preparation and megoestrol acetate. The uterus, removed at ovarohysterectomy, contained a large polypoid intraluminal mass with the histological features of endometrial carcinoma. The bitch has remained well for thirty-one months after surgery. The possibility is considered that the lesion is drug-related but no firm conclusion can be drawn about the precise nature and pathogenesis of this unusual lesion.
一只2岁未生育的杂种母犬在接受包括乙炔雌二醇/甲基睾酮复方制剂和醋酸甲地孕酮的治疗后，出现持续性外阴分泌物。在卵巢子宫切除术中切除的子宫内有一个大的息肉样腔内肿块，具有子宫内膜癌的组织学特征。这只母犬术后31个月一直状况良好。考虑到该病变可能与药物有关，但对于这种不寻常病变的确切性质和发病机制无法得出确凿结论。
